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1405-20-5

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Polymyxin B sulfate USP
Cas No: 1405-20-5
No Data 125 Gram Metric Ton/Day Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier
Polymyxin B sulfate
Cas No: 1405-20-5
No Data No Data Metric Ton/Day TAIZHOU SHASIN PHARMACHEM CO.,LTD Contact Supplier
Polymyxin B sulfate Manufacturer/High quality/Best price/In stock
Cas No: 1405-20-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
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Cas No: 1405-20-5
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
High quality Polymyxin B sulphate (current EP and USP)
Cas No: 1405-20-5
USD $ 1.0-1.0 / Kilogram 10 Kilogram 50 Metric Ton/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier
CAS: 1405-20-5 Polymyxin B sulfate factory sales
Cas No: 1405-20-5
No Data 1 Kilogram 100 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
Good quality USP Polymyxin B sulfate Cas 1405-20-5 with reasonable price
Cas No: 1405-20-5
USD $ 2800.0-2985.0 / Kilogram 1 Kilogram 1 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
High purity polymyxin B CAS:1405-20-5
Cas No: 1405-20-5
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Fresh In Stock:Polymyxin B Sulphate with BEST PRICE
Cas No: 1405-20-5
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Scale Chemical Corporation Contact Supplier
High quality Polymyxin B Sulphate supplier in China
Cas No: 1405-20-5
No Data No Data No Data Simagchem Corporation Contact Supplier

1405-20-5 Usage

Uses

Biochemical studies.
Polymyxin B is a kind of anti-Gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of Gram-negative bacteria. It has bactericidal effect on Escherichia coli through binding to the lipid A portion of bacterial lipopolysaccharide. Mechanism of action: bind and interfere with the permeability o the cellular membrane. Anti-bacteria spectrum: gram negative bacteria.

Injection polymyxin B sulfate manufacturer

Shanghai “Xin Xianfeng” Pharmaceutical Co., Ltd. Zhunzi H31022973
Shanghai No. 1 Biochemical Pharmaceutical Co., Ltd. Zhunzi H31022631

Uses

Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixtu re of Polymyxin B1 and B2 sulfate. Biological potency (dry basis): >6000U/mg.

Indications

Polymyxin B sulfate is similar with polymyxin E, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Escherichia coli deputy, Klebsiella pneumoniae, acidophilus, Bordetella pertussis and Shigella dysentery. It is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by Pseudomonas aeruginosa and other kinds of pseudomonas. It can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and Pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.

Uses

antibacterial

Drug Interactions

We should avoid apply it in combination with drugs causing significant damage to the kidneys, skeletal muscle relaxants, aminoglycoside antibiotics, and anesthetic drugs with significant effect of muscle relaxation (such as enflurane). Also we should avoid simultaneous intravenous administration of quinine, and magnesium. Combining polymyxin B sulfate with sulfa drugs, rifampicin, and semi-synthetic penicillin has a better efficacy than single application in treating severe infections resistant Gram-negative bacteria.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Dosage

1. Intravenous injection: Adults and children with normal renal function: 1.5 to 2.5 mg per kilogram of body weight per day (for per kg body weight, generally apply not more than 2.5 mg), divide into 2 times with 1 time every 12 hours of infusion. Dilute every 50mg of the product with 500 mL of 5% glucose solution and further add drop wise. Babies with normal renal function can tolerate a amount of 4 mg/day per kilogram of body weight.
2. Intramuscular injection: Adults and children: apply 2.5 to 3 mg per kilogram of body weight; apply in divided doses with applying 1 time every 4 to 6 hours. For baby, the dosage can be 4 mg per day per kilogram of body weight. For new born children, we can apply to 4.5 mg per time per kilogram of body weight.
3. intrathecal injection (for Pseudomonas aeruginosa meningitis): Each mL of drug solution prepared by the sodium chloride injection contains 5mg. Adults and children with over 2 years of age, apply 5 mg daily; after application of 3 to 4 days, change one time every other day, and continue for at least 2 weeks until the result of cerebrospinal fluid culture becomes negative and the sugar inspection becomes normal. For children less than 2 years of age, apply 2mg 1 time per day for continuous 3 to 4 days (or 2.5mg per every other day); after that, apply 2.5mg every other day, until the test becomes normal.
4. The ophthalmic solution concentration: 1~2.5mg per milliliter.

Brand name

(GlaxoSmithKline); Poly-Rx (X Gen).

Chemical Properties

White Solid

Precautions

1. Pregnant and lactating women, children, patients with severe kidneys damage and severe kidney dysfunction should either take with caution or reduce the administrated amount.
2. this product has relative large toxicity and a poor efficacy in treating deep tissue infection. It is also not the primary choice of drug for treating any kinds of infection.
3. intravenous injection may lead to respiratory depression and thus should generally not used. Half of the amount in daily dose should subject to intravenous drip, and can’t subject to disposable rapid bolus avoid extensive neuromuscular blockade.
4. it shouldn’t be used in combination with drugs with other renal toxicity or neuromuscular blocking effects to avoid accidents.
InChI:InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

1405-20-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1547007)  Polymyxin B sulfate  United States Pharmacopeia (USP) Reference Standard 1405-20-5 1547007-200MG 4,662.45CNY Detail
Sigma-Aldrich (P2400000)  Polymyxin B sulfate  European Pharmacopoeia (EP) Reference Standard 1405-20-5 P2400000 1,880.19CNY Detail
TCI America (P1923)  Polymyxin B Sulfate   1405-20-5 5g 2,220.00CNY Detail
TCI America (P1923)  Polymyxin B Sulfate   1405-20-5 1g 635.00CNY Detail

1405-20-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Polymyxin B sulfate

1.2 Other means of identification

Product number -
Other names PolymyxineBsulfate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1405-20-5 SDS

1405-20-5Downstream Products

1405-20-5Related news

Antimicrobial gelatin-based elastomer nanocomposite membrane loaded with ciprofloxacin and Polymyxin B sulfate (cas 1405-20-5) in halloysite nanotubes for wound dressing09/25/2019

Bacterial infection is a major problem world-wide, especially in wound treatment where it can severely prolong the healing process. In this study, a double drug co-delivery elastic antibacterial nanocomposite was developed by combining ciprofloxacin (CPX) and polymyxin B sulfate-loaded halloysit...detailed

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