1405-41-0

Basic information

• Product Name: Gentamycin sulfate
• Synonyms: GENTAMICIN 2,5-SULFATE HYDRATE;genoptics.o.p.;gentalline;gentamicinsolution;nsc-82261;sch9724;gentamicin solution 10mg/ml sterile*filtered;gentamicin solution cell culture tested
• CAS NO: 1405-41-0
• Molecular Formula: C60H127N15O26S
• Molecular Weight: 1506.8
• EINECS: 215-778-9
• Product Categories: Active Pharmaceutical Ingredients;All Inhibitors;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;AminoglycosidesCell Culture;AntibioticsNeural Stem Cell Biology;AntibioticsStem Cell Expansion;Culture;Interferes with Protein SynthesisMore...Close...;Neural Stem Cell Isolation/Expansion;Reagents and Supplements;Antibiotics G-MSerum-free Media;Hybridoma ReagentsAntibiotics;A - KAntibiotics;AminoglycosidesAntibiotics;Antibacterial;Antibiotics A to;Chemical Structure Class;Hybridoma Platform;Interferes with Protein Synthesis;Mechanism of Action;Spectrum of Activity;AminoglycosidesResearch Essentials;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Core Bioreagents;Antibiotics G-MAnalytical Standards;GAntibiotics;Alphabetic;API's;Peptide Synthesis/Antibiotics;Oligosaccharides;GARAMYCIN;antibiotic;Antibiotic and Antimicrobial Agents
• Mol File: 1405-41-0.mol

Chemical Properties

• Melting Point: 218-237°C
• Boiling Point: 797.6 °C at 760 mmHg
• Flash Point: 436.2 °C
• Appearance: colorless to light yellow/powder
• Density: 1.000 g/cm3
• Storage Temp.: 2-8°C
• Solubility: H2O: 50 mg/mL As stock solution, store at −20°
• Water Solubility: Soluble in water
• Merck: 13,4403
• CAS DataBase Reference: Gentamycin sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: Gentamycin sulfate(1405-41-0)
• EPA Substance Registry System: Gentamycin sulfate(1405-41-0)

Safety Data

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 23-36/37-45-22-24/25
• WGK Germany: 2
• RTECS: LY2625000
• F: 3
• Hazardous Substances Data: 1405-41-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Gentamycin sulfate is used as a broad-spectrum antibiotic for both topical and systemic applications, exhibiting bactericidal action. It is particularly effective against a wide range of bacteria and is used to treat various infections.
Used in Ophthalmic Drugs:
Gentamycin sulfate is used as an ingredient in ophthalmic drugs due to its antibacterial properties, helping to treat eye infections and maintain ocular health.
Used as an Antibacterial Agent:
Gentamycin sulfate inhibits protein synthesis by binding to the L6 protein of the 50S ribosomal subunit, making it an effective antibacterial agent.
Antibiotic Complex:
The antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and gentamicin A, which is similar to Kanamycin C. These components contribute to the overall effectiveness of gentamycin sulfate as an antibiotic.
Chemical Properties:
Gentamycin sulfate is a white to buff-colored powder with chemical properties that make it suitable for use in the pharmaceutical and ophthalmic industries. Its pH range of 3.5 to 5.5 ensures stability and effectiveness in various applications.
Please note that gentamycin sulfate has pharmaceutical incompatibilities with substances such as amphotericin, cephalosporins, erythromycin, heparin, penicillins, sodium bicarbonate, and sulfadiazine sodium.

Therapeutic Function

Antibacterial

Air & Water Reactions

Water soluble. Hygroscopic.

Reactivity Profile

Gentamycin sulfate is very stable in solution, even in moderately acidic to strongly basic aqueous media.

Fire Hazard

Flash point data for Gentamycin sulfate are not available; however, Gentamycin sulfate is probably combustible.

Biochem/physiol Actions

Mode of Action: Gentamicin inhibits protein synthesis by binding to the 30S subunit of the ribosome.Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Safety Profile

Poison by intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by subcutaneous route. Human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. See also other gentamycin entries.

InChI:InChI=1/C19H39N5O7.H2O4S/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m0./s1

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