1405-41-0

Basic information

• Product Name: Gentamycin sulfate
• Synonyms: GENTAMICIN 2,5-SULFATE HYDRATE;genoptics.o.p.;gentalline;gentamicinsolution;nsc-82261;sch9724;gentamicin solution 10mg/ml sterile*filtered;gentamicin solution cell culture tested
• CAS NO: 1405-41-0
• Molecular Formula: C60H127N15O26S
• Molecular Weight: 1506.8
• EINECS: 215-778-9
• Product Categories: Active Pharmaceutical Ingredients;All Inhibitors;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;AminoglycosidesCell Culture;AntibioticsNeural Stem Cell Biology;AntibioticsStem Cell Expansion;Culture;Interferes with Protein SynthesisMore...Close...;Neural Stem Cell Isolation/Expansion;Reagents and Supplements;Antibiotics G-MSerum-free Media;Hybridoma ReagentsAntibiotics;A - KAntibiotics;AminoglycosidesAntibiotics;Antibacterial;Antibiotics A to;Chemical Structure Class;Hybridoma Platform;Interferes with Protein Synthesis;Mechanism of Action;Spectrum of Activity;AminoglycosidesResearch Essentials;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Core Bioreagents;Antibiotics G-MAnalytical Standards;GAntibiotics;Alphabetic;API's;Peptide Synthesis/Antibiotics;Oligosaccharides;GARAMYCIN;antibiotic;Antibiotic and Antimicrobial Agents
• Mol File: 1405-41-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 218-237°C
• Boiling Point: 797.6 °C at 760 mmHg
• Flash Point: 436.2 °C
• Appearance: colorless to light yellow/powder
• Density: 1.000 g/cm3
• Storage Temp.: 2-8°C
• Solubility: H2O: 50 mg/mL As stock solution, store at −20°
• Water Solubility: Soluble in water
• Merck: 13,4403
• CAS DataBase Reference: Gentamycin sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: Gentamycin sulfate(1405-41-0)
• EPA Substance Registry System: Gentamycin sulfate(1405-41-0)

Safety Data

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 23-36/37-45-22-24/25
• WGK Germany: 2
• RTECS: LY2625000
• F: 3
• Hazardous Substances Data: 1405-41-0(Hazardous Substances Data)

Usage

Chemical Properties

White to buff-colored powder

Uses

Different sources of media describe the Uses of 1405-41-0 differently. You can refer to the following data:
1. This compound is a complex mixture of the sulfates of gentamycin Cl, gentamycin CIA and gentamycin C2. Pharmaceutical incompatibilites include amphotericin, cephalosporins, erythromycin, heparin, penicillins, sodium bicarbonate, and sulfadiazine sodium. It is used as topical and systemic broad-spectrum antibiotic with bactericidal action; also used in ophthalmic drugs.
2. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C. Gentamicin C1: R1=R2=CH3 Gentamicin C2: R1=CH3; R2=H Gentamicin C1A: R1=R2=H
3. Different viscosity grades available. Please inquire

Therapeutic Function

Antibacterial

General Description

Sulfate salt of an antibiotic complex produced by fermentation. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless.

Air & Water Reactions

Water soluble. Hygroscopic.

Reactivity Profile

Gentamycin sulfate is very stable in solution, even in moderately acidic to strongly basic aqueous media.

Fire Hazard

Flash point data for Gentamycin sulfate are not available; however, Gentamycin sulfate is probably combustible.

Biochem/physiol Actions

Mode of Action: Gentamicin inhibits protein synthesis by binding to the 30S subunit of the ribosome.Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Safety Profile

Poison by intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by subcutaneous route. Human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. See also other gentamycin entries.

InChI:InChI=1/C19H39N5O7.H2O4S/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m0./s1

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