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1405-86-3

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High quality of 1405-86-3 High purity of Glycyrrhizic acid A Buy
Cas No: 1405-86-3
USD $ 190.0-200.0 / Kilogram 20 Kilogram 5 Metric Ton/Year SHAANXI FUJIE PHARMACEUTICAL CO.,LTD Contact Supplier
1405-86-3/Glycyrrhizic acid
Cas No: 1405-86-3
USD $ 0.1-0.1 / Gram 1 Gram hundreds of Gram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Supply licorice root extract Glycyrrhizic acid 98%
Cas No: 1405-86-3
No Data 1 Kilogram 1 Metric Ton/Month Nanjing Manhay Medical Technology Co.,Ltd Contact Supplier
Whitening Cosmetics Ingreditent Liquorice Extract
Cas No: 1405-86-3
USD $ 15.0-40.0 / Kilogram 25 Kilogram 100000 Kilogram/Week Greenutra Resource Inc Contact Supplier
Glycyrrhizic acid Manufacturer/High quality/Best price/In stock
Cas No: 1405-86-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
99% up GMP Glycyrrhizic acid A 1405-86-3
Cas No: 1405-86-3
USD $ 825.0-1100.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Sinoway Industrial Co., Ltd. Contact Supplier
High quality Glycyrrhizic Acid supplier in China
Cas No: 1405-86-3
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Cosmetic ingredients Licorice root extract powder 98% Glycyrrhizic acid
Cas No: 1405-86-3
USD $ 10.0-100.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
Glycyrrhizinic acid 98% Purity CAS NO.1405-86-3
Cas No: 1405-86-3
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Natural White Licorice Root Extract Powder Glycyrrhizic Acid
Cas No: 1405-86-3
USD $ 308.0-339.0 / Kilogram 1 Kilogram 10000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier

1405-86-3 Usage

Description

Glycyrrhizic acid is a kind of anti-inflammatory triterpene glycoside extracted from the licorice root. Inside the body, it can be metabolized to glycyrrhetinic acid which inhibits the 11-beta-hydroxysteroid dehydrogenase and some other enzymes related to the corticosteroid metabolism. Glycyrrhizic acid has various pharmacological effects including suppressing hepatic apoptosis and necrosis, anti-inflammatory and immune regulatory actions, antiviral effects, antineoplastic and anticancer effects. It is the active ingredient of licorice root which is commonly used in the treatment of acute and chronic liver injury, viral hepatitis, hepatic steatosis, liver fibrosis, hepatoma, viral myocarditis and other diseases such as psoriasis or prostate cancer. Glycyrrhizic acid is also widely used as a sweetening and flavoring agent in food.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/ https://pubchem.ncbi.nlm.nih.gov/compound/Glycyrrhizic_acid#section=Top

Chemical Properties

White to off-white powder

Chemical Properties

Glycyrrhizin, also known as glycyrrhizic acid, is a glycoside isolated from the roots of licorice, Glycyrrhiza glabra L. For improved water solubility, an ammoniated salt is commonly used. This can be in the form of either ammonium glycyrrhizinate or monoammonium glycyrrhizinate.

Uses

Glycyrrhizin is a flavorant and foaming agent derived from the separation of flavonoids found in the whole licorice extract from the licorice root glycyrrhiza glabra. It is 50–100 times as sweet as sugar, is soluble in water, and has a licorice taste. It has good heat stability but prolonged heating can result in some degradation. It is stable within ph 4–9; below ph 4 there could be precipitation. It has foaming and emulsifying properties in water, being used in cocktail mixes and soft drinks. It is used as a flavorant in bacon and imitation whipped products. It is synergistic with sugar, the sweetness being amplified to 100 times that of cane sugar alone. It is used as a sweetener in sugar-free chewing gum and low-fat sugar-free frozen desserts. It is also termed ammoniated glycyrrhizin. Monoammonium glycyrrhizinate is obtained by additional refinement.

Uses

glycyrrhizic acid is a hydrolyzed glycyrrhizin. It is credited with antiinflammatory and anti-allergenic properties. Studies comparing glycyrrhizin with hydrocortisone found glycyrrhizin to be somewhat milder but longer lasting in effectiveness. once the application of hydrocortisone is suspended, the symptoms return. This does not appear to be the case with glycyrrhizin. It does not have side effects and is chemically stable so it can be safely used on a continuing basis.

Uses

11beta-hydroxysteroid dehydrogenase inhibitor, antiinflammatory, expectorant, antihaemorrhagic, anti-HIV

Uses

Glycyrrhizic acid is a triterpene saponin used in the traditional Chinese medicinal preparation for its anti-inflammatory , antiulcerous and antiallergic effects.

Definition

ChEBI: A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence and changes in the metabolism of phosphorus, When heated to decomposition it emits acrid smoke and irritating fumes.
InChI:InChI=1/C41H60O16.3H3N/c1-37(2)21-8-11-40(5)18-7-10-38(3)13-14-39(4,36(52)53)16-19(38)17(18)15-20(42)31(40)41(21,6)12-9-22(37)54-34-27(47)25(45)28(30(57-34)33(50)51)55-35-26(46)23(43)24(44)29(56-35)32(48)49;;;/h15,18-19,21-31,34-35,43-47H,7-14,16H2,1-6H3,(H,48,49)(H,50,51)(H,52,53);3*1H3/t18?,19-,21?,22-,23-,24-,25+,26+,27+,28-,29-,30-,31?,34+,35+,38-,39-,40-,41-;;;/m0.../s1

1405-86-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (G0150)  Glycyrrhizin  >93.0%(T) 1405-86-3 1g 195.00CNY Detail
TCI America (G0150)  Glycyrrhizin  >93.0%(T) 1405-86-3 25g 1,240.00CNY Detail
USP (1295888)  Glycyrrhizicacid  United States Pharmacopeia (USP) Reference Standard 1405-86-3 1295888-25MG 14,309.10CNY Detail

1405-86-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name glycyrrhizinic acid

1.2 Other means of identification

Product number -
Other names Glycyrrhizin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1405-86-3 SDS

1405-86-3Synthetic route

diammonium glycyrrhizinate

diammonium glycyrrhizinate

A

glycyrrhizin
1405-86-3

glycyrrhizin

B

18α-glycyrrhizic acid

18α-glycyrrhizic acid

Conditions
ConditionsYield
With sulfuric acid In methanol at 0℃; pH=3; Overall yield = 98 g;A n/a
B n/a
C45H68O15

C45H68O15

glycyrrhizin
1405-86-3

glycyrrhizin

Conditions
ConditionsYield
With sodium hydroxide for 2h; Reflux;8.5 g
trimethyl glycyrrhizate
30430-55-8

trimethyl glycyrrhizate

glycyrrhizin
1405-86-3

glycyrrhizin

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 2h; Heating; Yield given;
C42H62O12
149553-79-7

C42H62O12

glycyrrhizin
1405-86-3

glycyrrhizin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 31.3 percent / AgOTf, 1,1,3,3-tetramethylurea, Drierite / CH2Cl2 / 4 h / Ambient temperature
2: NaOMe / methanol / Ambient temperature
3: KOH / ethanol; H2O / 2 h / Heating
View Scheme
C44H61Cl3O13

C44H61Cl3O13

glycyrrhizin
1405-86-3

glycyrrhizin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 66.7 percent / NH3-sat. Et2O / 0.17 h / 0 °C
2: 31.3 percent / AgOTf, 1,1,3,3-tetramethylurea, Drierite / CH2Cl2 / 4 h / Ambient temperature
3: NaOMe / methanol / Ambient temperature
4: KOH / ethanol; H2O / 2 h / Heating
View Scheme
C55H78O21
60192-37-2

C55H78O21

glycyrrhizin
1405-86-3

glycyrrhizin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOMe / methanol / Ambient temperature
2: KOH / ethanol; H2O / 2 h / Heating
View Scheme
glycyrrhizin
1405-86-3

glycyrrhizin

AGR-GLY

AGR-GLY

Conditions
ConditionsYield
In water at 20℃; for 24h;95%
glycyrrhizin
1405-86-3

glycyrrhizin

strontium glycyrrhizinate

strontium glycyrrhizinate

Conditions
ConditionsYield
With strontium chloride In ethanol; water at 50℃; for 8h;93.7%
glycyrrhizin
1405-86-3

glycyrrhizin

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

C42H62O16*C42H70O35

C42H62O16*C42H70O35

Conditions
ConditionsYield
In ethanol; water for 0.333333h; Sonication;93.5%
Chloroquine
54-05-7

Chloroquine

glycyrrhizin
1405-86-3

glycyrrhizin

chloroquine glycyrrhizinate

chloroquine glycyrrhizinate

Conditions
ConditionsYield
In methanol at 55℃; for 8h; Inert atmosphere;91.5%
hydroxychloroquine

hydroxychloroquine

glycyrrhizin
1405-86-3

glycyrrhizin

hydroxychloroquine glycyrrhizinate

hydroxychloroquine glycyrrhizinate

Conditions
ConditionsYield
In methanol at 60℃; for 10h; Inert atmosphere;90.4%
glycyrrhizin
1405-86-3

glycyrrhizin

enoxolone
471-53-4

enoxolone

Conditions
ConditionsYield
With methanol; thionyl chloride at 0 - 20℃; for 9h; Reagent/catalyst; Inert atmosphere;90%
With hydrogenchloride; water In methanol at 90℃; for 20h;
With hydrogenchloride In water at 100℃; for 20h;
With sulfuric acid In methanol Reflux;250 mg
With methanol; sulfuric acid at 90℃; for 24h;
salicylic acid
69-72-7

salicylic acid

glycyrrhizin
1405-86-3

glycyrrhizin

8C42H62O16*C7H6O3

8C42H62O16*C7H6O3

Conditions
ConditionsYield
In ethanol at 20℃;85%
zinc(II) nitrate
10196-18-6

zinc(II) nitrate

water
7732-18-5

water

silver nitrate

silver nitrate

glycyrrhizin
1405-86-3

glycyrrhizin

silver zinc glycyrrhizinate

silver zinc glycyrrhizinate

Conditions
ConditionsYield
Stage #1: zinc(II) nitrate; silver nitrate; glycyrrhizin In ethanol at 50℃; for 8h; Darkness;
Stage #2: water at 60℃;
82.3%
methyl (L)-leucinate hydrochloride
7517-19-3

methyl (L)-leucinate hydrochloride

glycyrrhizin
1405-86-3

glycyrrhizin

C63H101N3O19

C63H101N3O19

Conditions
ConditionsYield
Stage #1: glycyrrhizin With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 24℃;
Stage #2: methyl (L)-leucinate hydrochloride With N-ethylmorpholine; In N,N-dimethyl-formamide at 22 - 24℃; for 24h;
80%
With benzotriazol-1-ol
glycyrrhizin
1405-86-3

glycyrrhizin

p-methoxycinnamoyl chloride
42996-84-9, 34446-64-5

p-methoxycinnamoyl chloride

penta-O-p-methoxycinnamoylglycyrrhizic acid

penta-O-p-methoxycinnamoylglycyrrhizic acid

Conditions
ConditionsYield
With pyridine; tributyl-amine In 1,2-dichloro-ethane 1.) 20-22 deg C, 2 h, 2.) 60-65 deg C, 12 h;69%
glycyrrhizin
1405-86-3

glycyrrhizin

A

2-[4,5-dihydroxy-6-hydroxymethyl-2-(11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14b-octadecahydro-picen-3-yloxy)-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

2-[4,5-dihydroxy-6-hydroxymethyl-2-(11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14b-octadecahydro-picen-3-yloxy)-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

B

2-[4,5-dihydroxy-6-hydroxymethyl-2-(11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydro-picen-3-yloxy)-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

2-[4,5-dihydroxy-6-hydroxymethyl-2-(11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydro-picen-3-yloxy)-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 4h; Reduction;A 30%
B 63%
glycyrrhizin
1405-86-3

glycyrrhizin

trimethyl glycyrrhizate
30430-55-8

trimethyl glycyrrhizate

Conditions
ConditionsYield
In methanol61.9%
2-acetamido-2-deoxy-β-D-glucopyranosylamine
4229-38-3, 102039-79-2, 115350-20-4, 133677-75-5, 137493-97-1

2-acetamido-2-deoxy-β-D-glucopyranosylamine

glycyrrhizin
1405-86-3

glycyrrhizin

C58H90N4O24

C58H90N4O24

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In pyridine; DMF (N,N-dimethyl-formamide)60%
With dicyclohexyl-carbodiimide In pyridine; DMF (N,N-dimethyl-formamide)42%
glycyrrhizin
1405-86-3

glycyrrhizin

salicyloyl chloride
1441-87-8

salicyloyl chloride

penta-O-salicyloylglycyrrhizic acid

penta-O-salicyloylglycyrrhizic acid

Conditions
ConditionsYield
With pyridine; tributyl-amine In 1,2-dichloro-ethane at 65 - 70℃; for 14h;58.1%
glycyrrhizin
1405-86-3

glycyrrhizin

1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid
34096-83-8

1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid

Conditions
ConditionsYield
With potassium dihydrogenphosphate; magnesium sulfate; urea In water at 30℃; for 72h; pH=6; Enzymatic reaction;54%
L-methionine-tert-butyl-ester.HCl
91183-71-0

L-methionine-tert-butyl-ester.HCl

glycyrrhizin
1405-86-3

glycyrrhizin

C60H96N2O18S2
1200807-15-3

C60H96N2O18S2

Conditions
ConditionsYield
Stage #1: glycyrrhizin With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In 1,4-dioxane at 0 - 5℃;
Stage #2: L-methionine-tert-butyl-ester.HCl With triethylamine In 1,4-dioxane at 20 - 22℃; for 24h;
52%
2,4-dinitrobenzoyl chloride
20195-22-6

2,4-dinitrobenzoyl chloride

glycyrrhizin
1405-86-3

glycyrrhizin

C56H66N4O26

C56H66N4O26

Conditions
ConditionsYield
With pyridine; tributyl-amine 1.) 60-70 deg C, 14 h, 2.) rt, overnight;50%
glycyrrhizin
1405-86-3

glycyrrhizin

O-acetylsalicyloyl chloride
5538-51-2

O-acetylsalicyloyl chloride

penta-O-acetylsalicyloylglycyrrhizic acid

penta-O-acetylsalicyloylglycyrrhizic acid

Conditions
ConditionsYield
With pyridine; tributyl-amine for 6h; Ambient temperature;49.5%

1405-86-3Upstream product

1405-86-3Related news

Research PaperEffects of manganese on accumulation of Glycyrrhizic acid (cas 1405-86-3) based on material ingredients distribution of Glycyrrhiza uralensis09/30/2019

Wild and cultivated Licorice (Glycyrrhiza uralensis FISCH.) are the main source of licorice. In recent years, wild Glycyrrhiza plants have been seriously damaged and this has reduced the population. The cultivation of Licorice has been the best way to solve the problem of its shortage. The conte...detailed

Glycyrrhizic acid (cas 1405-86-3) suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice09/28/2019

Diabetic patients are at an increased risk of developing severe and progressive periodontitis. Periodontal disease also increases the severity of diabetes by enhancing insulin resistance. Therefore, the regulation of periodontal inflammation in diabetic patients may contribute to the control of ...detailed

Glycyrrhizic acid (cas 1405-86-3) improving the liver protective effect by restoring the composition of Lactobacillus09/26/2019

Glycyrrhizic acid (GL) and its deglycosylated metabolite glycyrrhetinic acid (GA) have been recognized as effective drugs for liver diseases. However, the underlying molecular mechanism of GL and GA remains unclear. Here, CCl4 was used to induce the liver cirrhosis in rat, GL and GA both signifi...detailed

Glycyrrhizic acid (cas 1405-86-3) derivatives as Dengue virus inhibitors09/24/2019

Dengue virus (DENV) is one of the most geographically distributed pathogenic flaviviruses transmitted by mosquitoes Aedes sps. In this study, the structure-antiviral activity relationships of Glycyrrhizic acid (GL) derivatives was evaluated by the inhibitory assays on the cytopathic effect (CPE)...detailed

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