14050-66-9 Usage
Description
Phosphoribosylamine, also known as 5-phosphoribosyl-1-amine, is a vital intermediate in the biosynthesis of purine and pyrimidine nucleotides. It is synthesized through the condensation of 5-phosphoribosyl-1-pyrophosphate (PRPP) and ammonia, catalyzed by the enzyme glutamine-PRPP amidotransferase. Phosphoribosylamine plays a crucial role in the formation of nucleotide bases adenine and guanine, which are essential for the synthesis of DNA and RNA. These bases are vital for cellular processes such as gene expression, protein synthesis, and energy transfer. As a key intermediate in the regulation of nucleotide biosynthesis and cellular metabolism, phosphoribosylamine is indispensable for maintaining cellular function and integrity.
Uses
Used in Pharmaceutical Industry:
Phosphoribosylamine is used as a precursor in the synthesis of nucleotide bases adenine and guanine for the development of drugs targeting various diseases. Its role in the biosynthesis of DNA and RNA makes it a potential target for therapeutic interventions in conditions related to genetic disorders, cancer, and viral infections.
Used in Biochemical Research:
Phosphoribosylamine is utilized as a research tool in biochemical studies to investigate the mechanisms of nucleotide biosynthesis, cellular metabolism, and the regulation of gene expression. It helps researchers understand the molecular pathways involved in various biological processes and develop targeted therapies for diseases.
Used in Diagnostic Applications:
Phosphoribosylamine can be employed as a biomarker in diagnostic assays to monitor the activity of enzymes involved in nucleotide biosynthesis. Abnormal levels of phosphoribosylamine may indicate deficiencies or imbalances in cellular metabolism, providing valuable information for the diagnosis and management of metabolic disorders and genetic diseases.
Used in Nutritional Supplements:
Phosphoribosylamine may be used as a nutritional supplement to support the synthesis of nucleotides and maintain optimal cellular function. It can be incorporated into dietary supplements or functional foods to promote overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 14050-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,5 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14050-66:
(7*1)+(6*4)+(5*0)+(4*5)+(3*0)+(2*6)+(1*6)=69
69 % 10 = 9
So 14050-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H12NO7P/c6-5-4(8)3(7)2(13-5)1-12-14(9,10)11/h2-5,7-8H,1,6H2,(H2,9,10,11)/t2-,3-,4-,5?/m1/s1
