1405128-38-2

Basic information

• Product Name: tert-butyl (3S,5R)-5-fluoropiperidin-3-ylcarbamate
• Synonyms: tert-butyl (3S,5R)-5-fluoropiperidin-3-ylcarbaMate;tert-butyl N-[(3S,5R)-5-fluoropiperidin-3-yl]carbamate
• CAS NO: 1405128-38-2
• Molecular Formula: C₁₀H₁₉FN₂O₂
• Molecular Weight: 218.14
• EINECS: -0
• Mol File: 1405128-38-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (3S,5R)-5-fluoropiperidin-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3S,5R)-5-fluoropiperidin-3-ylcarbamate(1405128-38-2)
• EPA Substance Registry System: tert-butyl (3S,5R)-5-fluoropiperidin-3-ylcarbamate(1405128-38-2)

Safety Data

• Hazardous Substances Data: 1405128-38-2(Hazardous Substances Data)

Upstream product

• 1052715-29-3 (3R,5R)-benzyl 3-fluoro-5-hydroxypiperidine-1-carboxylate 
• 1318129-78-0 methyl (2R,4R)-1-(4-methoxybenzyl)-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 1611481-36-7 ((2S,4S)-4-amino-1-tritylpyrrolidin-2-yl)methanol 
• 1611480-94-4 tert-butyl ((3S,5R)-5-fluoro-1-(4-methoxybenzyl)piperidin-3-yl)carbamate 
• 1611480-91-1 tert-butyl (3S,5R)-5-fluoro-1-tritylpiperidin-3-ylcarbamate 
• 1611480-89-7 tert-butyl (3S,5S)-5-(hydroxymethyl)-1-(4-methoxybenzyl)pyrrolidin-3-ylcarbamate 
• 1611480-88-6 N-((3S,5S)-5-(hydroxymethyl)-1-tritylpyrrolidin-3-yl)benzamide 
• 1611480-85-3 (2S,4S)-methyl 4-azido-1-(4-methoxybenzyl)pyrrolidine-2-carboxylate 
• 1611480-84-2 (2S,4S)-methyl 4-azido-1-tritylpyrrolidine-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 1611480-81-9 methyl (2S,4R)-4-hydroxy-1-[(4-methoxyphenyl)methyl]pyrrolidine-2-carboxylate 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 1611481-00-5 C₁₇H₂₃FN₂O₃ 
• 1611481-01-6 ((3S,5R)-3-amino-5-fluoropiperidin-1-yl)(phenyl)methanone 
• 1611481-07-2 tert-butyl (3S,5R)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate 
• 1611481-08-3 ((3S,5R)-3-amino-5-fluoropiperidin-1-yl)(4-methoxyphenyl)methanone 
• 1611488-82-4 ((3S,5R)-3-amino-5-fluoropiperidin-1-yl)(3-methoxyphenyl)methanone 
• 1611488-81-3 ((3S,5R)-3-amino-5-fluoropiperidin-1-yl)(2-methoxyphenyl)methanone 
• 1611481-09-4 ((3S,5S)-3-amino-5-fluoropiperidin-1-yl)(4-nitrophenyl)methanone 
• 1611481-12-9 ((3S,5R)-3-amino-5-fluoropiperidin-1-yl)(4-nitrophenyl)methanone 
• 1611481-13-0 ((3S,5R)-3-amino-5-fluoropiperidin-1-yl)(3-nitrophenyl)methanone 
• 1611487-96-7 (3S,5R)-(9H-fluoren-9-yl)methyl 3-amino-5-fluoropiperidine-1-carboxylate hydrochloride 
• 1611488-00-6 N-((3S,5R)-5-fluoropiperidin-3-yl)-4-nitrobenzamide 
• 1611488-01-7 N-((3S,5R)-5-fluoropiperidin-3-yl)-3-nitrobenzamide 
• 1611488-02-8 N-((3S,5R)-5-fluoropiperidin-3-yl)-2-nitrobenzamide 
• 1052715-31-7 (3S,5R)-benzyl 3-((tert-butoxycarbonyl)amino)-5-fluoropiperidine-1-carboxylate 

Relevant articles and documents

PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS

The invention relates to bicyclic compounds of formulas I and I', and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

The present invention relates to new compounds of Formulas (I) and (II), their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmac