14054-17-2

Usage

Uses

Used in Pharmaceutical Industry:
Morphinanium,7,8-didehydro-4,5-epoxy-3,6-dihydroxy-17,17-dimethyl-, iodide (1:1), (5a,6a)is used as a pain reliever for various types of acute and chronic pain conditions, including post-operative pain, cancer pain, and severe injury-related pain. Its potent analgesic effects make it a crucial component in the management of severe pain.
Morphinanium,7,8-didehydro-4,5-epoxy-3,6-dihydroxy-17,17-dimethyl-, iodide (1:1), (5a,6a)is also used as a cough suppressant, particularly for dry, non-productive coughs. It works by suppressing the cough reflex in the brain, providing relief from persistent coughing.
In addition to its primary uses, Morphine is also utilized in the development of other opioid medications, which may have different potencies, durations of action, or routes of administration, catering to various medical needs and patient preferences.

Upstream product

• 57-27-2 MORPHIN 
• 74-88-4 methyl iodide 
• 143-70-4 morphine 

Relevant academic research and scientific papers

Clearance and analgesic activity of the quaternized opiate, N-methyl-morphine [6-3H] administered intracisternally to the rat

The authors report on the preparation, clearance and analgesic activity of N-methylmorphine [6-3H] administered intracisternally to the rat and show that the analgesia is due to the quaternary compound and not to an in vivo conversion to the te

USE OF OPIOID COMPOUNDS IN PERIPHERAL PAIN, WOUND HEALING AND SCAR FORMATION

A compound which is a quaternary ammonium salt derivative of an opioid, for use in therapy.

Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water

Herein we describe an extensive study of the response of a set of closely related dynamic combinatorial libraries (DCLs) of macrocyclic receptors to the introduction of a focused range of guest molecules. We have determined the amplification of two sets of diastereomeric receptors induced by a series of neutral and cationic guests, including biologically relevant compounds such as acetylcholine and morphine. The host-guest binding affinities were investigated using isothermal titration calorimetry. The resulting dataset enabled a detailed analysis of the relationship between the amplification of selected receptors and host-guest Gibbs binding energies, giving insight into the factors affecting the design, simulation and interpretation of DCL experiments. In particular, two questions were addressed: Is amplification by a given guest selective for the best receptor? And does the best guest induce the largest amplification of a given receptor? Our experimental results and computer simulations showed that the relative levels of amplification of hosts by a guest are well-correlated with their relative affinities, and simulations have confirmed previous observations that amplification can be selective for the best receptor when only modest amounts of guest are used. In contrast, the correlation between guest binding and the extent of amplification of a given receptor across a wide range of guests tends to be poorer, because every guest has its own unique set of affinities for competing receptors in the DCL. This implies that the results of screening a DCL for selective receptors by comparing the response of the mixture to two different guests should be interpreted with caution. DCLs are complex mixtures in which all compounds are connected through a set of equilibria. Obtaining quantitative information about all host-guest binding constants from such systems will require the explicit and simultaneous consideration of all of the main equilibria within a DCL.

Diastereoisomeric quaternary morphinium salts: Synthesis, stereochemistry and analgesic properties

Diastereoisomeric quaternary morphinium salts were prepared by alkylation of morphine with alkyl halides or by alkylation of N-alkylnormorphines with methyl iodide. Nitrogen configuration of diastereoisomeric pairs was assigned by means of 1H NMR chemical shifts of corresponding N-methyl protons. These compounds were evaluated for analgesic activity by the guinea pig ileum assay and by the hot-plate test after icv administration in mice. The correlation between N-substituent orientation and narcotic agonist/antagonist activity is discussed.