14062-26-1

Basic information

• Product Name: ethyl (4-phenoxyphenyl)acetate
• CAS NO: 14062-26-1
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.2964
• Mol File: 14062-26-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 353.8°C at 760 mmHg
• Flash Point: 147.3°C
• Density: 1.117g/cm³
• Vapor Pressure: 3.51E-05mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: ethyl (4-phenoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (4-phenoxyphenyl)acetate(14062-26-1)
• EPA Substance Registry System: ethyl (4-phenoxyphenyl)acetate(14062-26-1)

Safety Data

• Hazardous Substances Data: 14062-26-1(Hazardous Substances Data)

Usage

General Description

Ethyl (4-phenoxyphenyl)acetate is a chemical compound with the formula C12H14O3. It is commonly used as a fragrance ingredient in perfumes and personal care products due to its sweet, floral, and fruity odor. ethyl (4-phenoxyphenyl)acetate is a clear, colorless liquid with a low volatility, making it an ideal ingredient for long-lasting and stable fragrance formulations. Ethyl (4-phenoxyphenyl)acetate is also used in the flavor industry to add a fruity and floral note to food and beverage products. Its versatile aroma profile allows it to be used in a wide range of applications, from cosmetics to household products.

Upstream product

• 101-55-3 4-Bromodiphenyl ether 
• 105-53-3 diethyl malonate 
• 6328-74-1 4-phenoxyphenylacetic acid 
• 104-15-4 toluene-4-sulfonic acid 
• 64-17-5 ethanol 
• 623-73-4 diazoacetic acid ethyl ester 
• 101-84-8 diphenylether 

Downstream Products

• 103210-74-8 1,3-bis-(4-phenoxy-phenyl)-acetone 
• 219311-20-3 5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione 
• 123056-20-2 2,5-bis-(4-phenoxy-phenyl)-3,4-diphenyl-cyclopentadienone 
• 64723-44-0 Toluene-4-sulfonic acid 2-(4-phenoxy-phenyl)-ethyl ester 
• 107291-94-1 7-Phenoxy-isothiochroman-1-carboxylic acid ethyl ester 
• 107291-86-1 Chloro-[2-(4-phenoxy-phenyl)-ethylsulfanyl]-acetic acid ethyl ester 
• 107291-79-2 [2-(4-Phenoxy-phenyl)-ethylsulfanyl]-acetic acid ethyl ester 
• 107292-00-2 7-phenoxyisothiochroman-1-carboxylic acid 
• 52446-51-2 2-(4-phenyloxyphenyl)ethyl alcohol 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Regioselective Arene C?H Alkylation Enabled by Organic Photoredox Catalysis

Expanding the toolbox of C?H functionalization reactions applicable to the late-stage modification of complex molecules is of interest in medicinal chemistry, wherein the preparation of structural variants of known pharmacophores is a key strategy for drug development. One manifold for the functionalization of aromatic molecules utilizes diazo compounds and a transition-metal catalyst to generate a metallocarbene species, which is capable of direct insertion into an aromatic C?H bond. However, these high-energy intermediates can often require directing groups or a large excess of substrate to achieve efficient and selective reactivity. Herein, we report that arene cation radicals generated by organic photoredox catalysis engage in formal C?H functionalization reactions with diazoacetate derivatives, furnishing sp2–sp3 coupled products with moderate-to-good regioselectivity. In contrast to previous methods utilizing metallocarbene intermediates, this transformation does not proceed via a carbene intermediate, nor does it require the presence of a transition-metal catalyst.

Barbituric acid derivatives with antimetastatic and antitumor activity

The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for preparing the derivatives, and methods for treating diseases associated with elevated or uncontrolled levels of matrix metalloprotease activity, e.g., cancer, specifically tumor progression and tumor metastasis, inflammation, or as a method of contraception.