140630-47-3

Upstream product

• 128878-93-3 (2S)-2-Hydroxy-2-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-butyn-1-yl 2,2-dimethylpropanoate 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 140429-10-3 (2S)-2-<(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl>-3-butyn-1,2-diol 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 

Relevant academic research and scientific papers

Synthetic studies on the compounds related to neocarzinostatin chromophore. 1. Synthesis of the acyclic (E)-and (Z)-dienediyne systems

The stereo-defined (E)- and (Z)-dienediyne systems related to neocarzinostatin chromophore (1) could be prepared by the coupling reaction of (E)- and (Z)-enol triflates with optically active acetylynes bearing the correct absolute stereochemistries as found in 1. Comparison of cytotoxic level of the (E)-and (Z)-dienediyne diols (32 and 33) revealed that the stereochemistry of exo-trisubstituted double bond might have a posibility to control the cytotoxicity of the acyclic analogues related to 1.