Tetrahedron p. 633 - 650 (1992)
Update date:2022-07-31
Topics:
Nakatani, Kazuhiko
Arai, Katsuko
Hirayama, Noriaki
Matsuda, Fuyuhiko
Terashima, Shiro
The stereo-defined (E)- and (Z)-dienediyne systems related to neocarzinostatin chromophore (1) could be prepared by the coupling reaction of (E)- and (Z)-enol triflates with optically active acetylynes bearing the correct absolute stereochemistries as found in 1. Comparison of cytotoxic level of the (E)-and (Z)-dienediyne diols (32 and 33) revealed that the stereochemistry of exo-trisubstituted double bond might have a posibility to control the cytotoxicity of the acyclic analogues related to 1.
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