14064-83-6

Basic information

• Product Name: 4-Hydroxy-4'-nitrostilbene
• Synonyms: 4-HYDROXY-4''-NITROSTILBENE ---ORANGE CRYSTALS---
• CAS NO: 14064-83-6
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.25
• Mol File: 14064-83-6.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Hydroxy-4'-nitrostilbene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-4'-nitrostilbene(14064-83-6)
• EPA Substance Registry System: 4-Hydroxy-4'-nitrostilbene(14064-83-6)

Safety Data

• Hazardous Substances Data: 14064-83-6(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 62-23-7 4-nitro-benzoic acid 
• 100-13-0 4-nitrostyrene 
• 4648-33-3 (E)-1-methoxy-4-(4-nitrostyryl)benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 131719-55-6 diethyl <4-(benzyloxy)benzyl>phosphonate 
• 24265-91-6 4-benzyloxy-4'-nitrostilbene 
• 104-03-0 4-nitrobenzeneacetic acid 
• 540-38-5 p-Iodophenol 
• 156-38-7 4-hydroxyphenylacetate 

Downstream Products

• 18951-43-4 4-Amino-4'-hydroxy-stilbene 
• 52785-67-8 trans-4'-Nitro-4-(α-carboxypropioxy)-stilben 
• 1260116-23-1 t-butyl(dimethyl){4-[(E)-2-(4-nitrophenyl)ethenyl]phenoxy}silane 
• 5455-87-8 4-methoxy-N-(4-nitrobenzylidene)aniline 
• 3230-50-0 4-(4-hydroxyphenyl)-N-(4-methoxyphenyl)imine 
• 16035-87-3 N-(p-nitrobenzyl)-p-anisidine 
• 73351-21-0 4-(((4-methoxyphenyl)amino)methyl)phenol 
• 33384-05-3 4-(4-aminophenethyl)phenol 
• 1426090-85-8 trans-4-nonyloxy-4'-nitrostilbene 

Relevant articles and documents

Stilbene-based anticancer agents: Resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism

Several stilbenes, related to known resveratrol, have been synthesized and tested for their anticancer effect on HL60 leukemia cell line, taking particular care of the cell cycle analysis. The most potent compound was the known (Z)-3,4′,5-trimethoxystilbe

Synthesis and cytotoxic effects on pancreatic cancer cells of resveratrol analogs

In this study, a series of resveratrol analogs was synthesized and the effects on the viability of pancreatic cancer cell lines were evaluated. The new molecules were designed by removing the 3- and 5-OH groups of resveratrol, and by incorporating other s

Chemo-enzymatic synthesis of (: E)-2,3-diaryl-5-styryl- trans -2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90)

Herein we propose a facile, versatile and selective chemo-enzymatic synthesis of substituted (E)-2,3-diaryl-5-styryl-trans-2,3-dihydrobenzofurans based on the exploitation of the laccase-mediated oxidative (homo)coupling of (E)-4-styrylphenols. Thanks to this novel synthetic strategy, a library of benzofuran-based potential allosteric activators of the Heat shock protein 90 (Hsp90) was easily prepared. Moreover, considering their structural analogies to previously reported allosteric modulators, the sixteen new compounds synthesized in this work were tested in vitro for their potential stimulatory action on the ATPase activity of the molecular chaperone Hsp90. Combining experimental and computational results, we propose a mechanism of action for these compounds, and expand the structure-activity relationship (SAR) information available for benzofuran-based Hsp90 activators.