140640-31-9Relevant academic research and scientific papers
Alkanoylation of quinazoline by nucleophilic aromatic substitution: Combined experimental and computational study
Suzuki, Yumiko,Iwata, Naoto,Dobashi, Kohei,Takashima, Ryo,Arulmozhiraja, Sundaram,Ishitsubo, Erika,Matsuo, Naoya,Tokiwa, Hiroaki
, p. 392 - 400 (2017/12/28)
A combined experimental and computational study on the key intermediates of NHC-catalyzed acylation reaction, Breslow intermediates (BIs), has been conducted in order to achieve a direct nucleophilic alkanoylation of N-heterocycles. Various BI precursors
Synthesis and structure-activity relationship study of 1-phenyl-1-(quinazolin-4-yl)ethanols as anticancer agents
Kuroiwa, Kenta,Ishii, Hirosuke,Matsuno, Kenji,Asai, Akira,Suzuki, Yumiko
, p. 287 - 291 (2015/03/30)
A quinazoline derivative PVHD121 (1a) was shown to have strong antiproliferative activity against various tumor-derived cell lines, including A549 (lung), NCI-H460 (lung), HCT116 (colon), MCF7 (breast), PC3 (prostate), and HeLa (cervical) cells with IC50 values from 0.1 to 0.3 M. A structure-activity relationship (SAR) study at the 2- and 4-position of the quinazoline core lead to the discovery of more potent anticancer agents (14, 16, 17, 19, 24, and 31). The results of an in vitro tubulin polymerization assay and fluorescent-based colchicine site competition assay with purified tubulin indicated that 1a inhibits tubulin polymerization by binding to the colchicine site.
Catalytic action of azolium salts. II. Aroylation of 4-chloroquinazolines with aromatic aldehydes catalyzed by 1,3-dimethylbenzimidazolium iodide
Miyashita,Matsuda,Iijima,Higashino
, p. 43 - 48 (2007/10/02)
When a mixture of 4-chloroquinazoline (7), an aromatic aldehyde 6, sodium hydride, and a catalytic amount of 1,3-dimethylbenzimidazolium iodide (1) in tetrahydrofuran (THF) was refluxed with stirring for an appropriate time, the chlorine atom of 7 was rep
