140654-19-9

Upstream product

• 140654-18-8 (3S,4R)-1-Benzyloxy-4-iodo-hexan-3-ol 
• 140654-18-8 (3S,4S)-1-Benzyloxy-4-iodo-hexan-3-ol 
• 121441-15-4 (3RS,4RS)-1-(benzyloxy)-3,4-epoxyhexane 
• 121441-15-4 (3RS,4SR)-1-(benzyloxy)-3,4-epoxyhexane 
• 925-90-6 ethylmagnesium bromide 
• 94426-72-9 2-(2-(benzyloxy)ethyl)oxirane 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST

Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.

Diols obtained via chemo and regioselective ring opening of epoxy alcohols: A straightforward synthesis of 2S,3S-octandiol

Epoxy alcohols are regio and chemoselectively opened to the corresponding iodohydrins and then reduced in situ to diols; the application of the described procedure leads to a short asymmetric of a well known pheromone. Also homoallylic (E and Z) epoxy alcohols and its benzylated derivatives shows high preference for regioselective opening affording the corresponding 1,3 diol.