140666-31-5

Upstream product

• 81745-84-8 2-thienylzinc chloride 
• 140666-28-0 N-(2-iodophenyl)4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide 
• 615-43-0 2-iodophenylamine 
• 61613-20-5 N-tosyl-2-iodoaniline 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

CONVERSION OF 2-IODOANILINE INTO (Z)-3-METHYLENE-2,3-DIHYDROINDOLE DERIVATIVES

Treatment of N-(2-iodophenyl)-N-2-propynyl-p-tolylsulfonamide with various organozinc chlorides in the presence of palladium acetate, triphenylphosphine, and 1 equiv. of triethylamine in tetrahydrofuran gives (Z)-3-alkylidene-2,3-dihydroindoles via intramolecular Heck-type reaction and successive cross coupling reactions.