140668-74-2Relevant academic research and scientific papers
Facile peptide thioester synthesis via solution-phase tosylamide preparation
Manabe, Shino,Sugioka, Tomoyuki,Ito, Yukishige
, p. 849 - 853 (2007/10/03)
Preparation of peptide thioester is essential for native chemical ligation and block condensation. Our novel methodology involves conversion of the carboxylic acid of a peptide into a thioester using p-toluenesulfonyl isocyanate, followed by alkylation, t
Reverse proteolysis promoted by in situ generated peptide ester fragments
Wehofsky, Nicole,Koglin, Norman,Thust, Sven,Bordusa, Frank
, p. 6126 - 6133 (2007/10/03)
In this contribution we describe a general synthesis concept for the in situ preparation of protease specific reactants using methyl thioesters as universal precursors. The precursor esters are readily available by standard synthesis procedures and can be
