928342-25-0Relevant academic research and scientific papers
Facile peptide thioester synthesis via solution-phase tosylamide preparation
Manabe, Shino,Sugioka, Tomoyuki,Ito, Yukishige
, p. 849 - 853 (2007/10/03)
Preparation of peptide thioester is essential for native chemical ligation and block condensation. Our novel methodology involves conversion of the carboxylic acid of a peptide into a thioester using p-toluenesulfonyl isocyanate, followed by alkylation, t
