140677-12-9Relevant articles and documents
Synthesis of marine alkaloid: 8,9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents
Gupta, Leena,Talwar, Archna,Nishi,Palne, Shraddha,Gupta, Suman,Chauhan, Prem M.S.
, p. 4075 - 4079 (2007)
A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 μg/ml.