140679-95-4Relevant academic research and scientific papers
New Antitumour Bicyclic Hexapeptides, RA-IX and -X from Rubia cordifolia. Part 3. Conformation-Antitumour Activity Relationship
Itokawa, Hideji,Yamamiya, Tetsuo,Morita, Hiroshi,Takeya, Koichi
, p. 455 - 460 (2007/10/02)
RA-IX and -X, new antitumour bicyclic hexapeptides were isolated from Rubia cordifolia and their structures were elucidated by spectroscopic and chemical evidences.RA-X containing a glutamic acid at residue 2 showed strong antitumour activity.However, RA-IX with conformation restricted to a type II β-turn at reidues 2 and 3 showed almost no antitumour activity.Their conformation-antitumour activity relationships are discussed.
