14068-53-2

Basic information

• Product Name: 2-Amino-5-ethyl-1,3,4-thiadiazole
• Synonyms: IFLAB-BB F1918-0074;2-AMINO-5-ETHYL-1,3,4-THIADIAZOLE;5-ETHYL-1,3,4-THIADIAZOL-2-AMINE;5-ETHYL-[1,3,4]THIADIAZOL-2-YLAMINE;AKOS BBS-00004451;4-thiadiazol-2-amine,5-ethyl-3;4-thiadiazole,2-amino-5-ethyl-3;5-ethyl-2,5-dihydro-1,3,4-thiadiazol-2-amine
• CAS NO: 14068-53-2
• Molecular Formula: C₄H₇N₃S
• Molecular Weight: 129.18
• EINECS: 237-921-4
• Product Categories: Amines;Oxadiazoles & Thiadiazoles;API intermediates;Oxadiazoles & Thiadiazoles;Building Blocks;Heterocyclic Building Blocks;Thiadiazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 14068-53-2.mol
• Article Data: 25

Chemical Properties

• Melting Point: 200-203 °C(lit.)
• Boiling Point: 267.2 °C at 760 mmHg
• Flash Point: 115.4 °C
• Appearance: /solid
• Density: 1.220 (estimate)
• Vapor Pressure: 0.00826mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.73±0.10(Predicted)
• BRN: 113614
• CAS DataBase Reference: 2-Amino-5-ethyl-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-ethyl-1,3,4-thiadiazole(14068-53-2)
• EPA Substance Registry System: 2-Amino-5-ethyl-1,3,4-thiadiazole(14068-53-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36/37/39-22-24/25
• WGK Germany: 3
• RTECS: XI3095000
• TSCA: Yes
• Hazardous Substances Data: 14068-53-2(Hazardous Substances Data)

Usage

Chemical Properties

LIGHT BEIGE CRYSTALLINE POWDER

Uses

2-Amino-5-ethyl-1,3,4-thiadiazole was used in the synthesis of:3-(5-ethyl-1,3,4-thiadiazol-2-yldiazenyl)-1-methyl-2-phenyl-1H-indolehetarylazoindole dyesN-(5-ethyl-[1,3,4]-thiadiazole-2-yl) toluenesulfonamide ligand

Definition

ChEBI: A member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by an amino group at position 2 and an ethyl group at position 5 respectively.

General Description

Influence of 2-amino-5-ethylthio-1,3,4-thiadiazole on inhibition of copper corrosion in an aerated 0.50M HCl solution has been investigated using gravimetric and electrochemical techniques.

InChI:InChI=1/C4H7N3S/c1-2-3-6-7-4(5)8-3/h2H2,1H3,(H2,5,7)

Upstream product

• 802294-64-0 propionic acid 
• 79-19-6 thiosemicarbazide 
• 107-12-0 propiononitrile 
• 96133-97-0 C₆H₁₃N₃OS 
• 41837-55-2 2-ethyl-7-methyl-5H-1,3,4-thiadiazolo<3,2-a>-pyrimidin-5-one 
• 115-80-0 Triethyl orthopropionate 
• 79-03-8 propionyl chloride 
• 20953-13-3 1-propanoyl-3-thiosemicarbazide 
• 22042-87-1 propionaldehyde thiosemicarbazone 
• 25958-42-3 N-(5-ethyl-1,3,4-thiadiazol-2-yl)propanamide 

Downstream Products

• 544431-10-9 2-cyano-N-(5-ethyl-[1,3,4]-thiadiazol-2-yl)acetamide 
• 450354-06-0 C₁₂H₁₀ClN₃S 
• 931317-43-0 C₁₃H₁₃N₃S 
• 940435-79-0 C₁₃H₁₃N₃OS 
• 36231-88-6 N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide 
• 313535-89-6 N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide 
• 313648-38-3 N-(5-ethyl-1,3,4-thiadiazol-2-yl)isobutyramide 
• 245526-90-3 O,O-diphenyl 1-(5-ethyl-1,3,4-thiadiazol-2-yl)amino-1-phenylmethylphosphonate 

Relevant articles and documents

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Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides

[Figure not available: see fulltext.] Unusual reaction proceeding via the electrophilic activation of nitroalkanes in the presence of polyphosphoric acid has been discovered. Subsequent nucleophilic attack with semicarbazides or thiosemicarbazides allows

2-ethyl-6-ferrocenyl-imidazo[2,1-b]-1,3,4-thiadiazole preparation method

The present invention discloses a 2-ethyl-6-ferrocenyl-imidazo[2,1-b]-1,3,4-thiadiazole preparation method, which comprises: carrying out stirring mixing on 2-amino-5-ethyl-1,3,4-thiadiazole, alpha-bromo-acetylferrocene and ethanol; placing the mixed solution in a microwave oven, and carrying out microwave irradiation; after the alpha-bromo-acetylferrocene completely reacts, carrying out a microwave reaction; adding water to the reaction solution, and adjusting the pH value of the reaction solution to 7-8 with a saturated sodium carbonate solution; carrying out suction filtration, washing the filter cake with water, and drying to obtain a crude product; and re-crystallizing with DMF to obtain the target product. According to the present invention, the microwave-assisted synthesis reaction is used so as to substantially shorten the reaction time and improve the reaction efficiency.