140694-90-2

Basic information

• Product Name: 1,4-anhydro-5-O-(triphenylmethyl)-D-ribitol
• Synonyms: 1,4-anhydro-5-O-(triphenylmethyl)-D-ribitol
• CAS NO: 140694-90-2
• Molecular Weight: 376.452
• Mol File: 140694-90-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,4-anhydro-5-O-(triphenylmethyl)-D-ribitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-anhydro-5-O-(triphenylmethyl)-D-ribitol(140694-90-2)
• EPA Substance Registry System: 1,4-anhydro-5-O-(triphenylmethyl)-D-ribitol(140694-90-2)

Safety Data

• Hazardous Substances Data: 140694-90-2(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 491-19-0 (2RS, 3RS, 4SR)-2-(hydroxymethyl)tetrahydrofuran-3,4-diol 
• 87-99-0 XYLITOL 
• 491-19-0 1,4-anhydro-D-ribitol 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 
• 162635-55-4 1,4-anhydro-2,3-O-isopropylidene-5-O-(triphenylmethyl)-D-ribitol 
• 5336-08-3 D-Ribono-1,4-lactone 
• 1122-58-3 dmap 
• 106707-71-5 2,3,5-tri-O-acetyl-1,4-anhydro-D-ribitol 

Downstream Products

• 3169-90-2 O²,O³-diacetyl-O⁵-trityl-DL-1,4-anhydro-xylitol 
• 162635-56-5 (2S)-2-O-(2-hydroxyethyl)-1-O-triphenylmethylglycerol 

Relevant articles and documents

IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY

The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) Wherein R1 includes an amino group. These compounds are particularly useful in the formulation and in vivo and ex vivo delivery of nucleic acid and protein therapeutics for preparing and implementing T cell transfection, gene editing, cancer therapies, cancer prophylactics, and in the preparation of vaccines.

A new route to some enantiomerically pure substituted morpholines from D-ribono- and D-gulono-1,4-lactones

D-Ribono-1,4-lactone, after acetalation, tritylation, and reduction, leads to a cyclization compound which gave with tosyl chloride 1,4-anhydro-2,3-O-isopropylidene-5-O-trityl-D-ribitol.The latter was transformed (acid hydrolysis, periodate oxidation, reduction, tritylation, and tosylation) into a ditosylated derivative 16, which was cyclized into morpholines by the action of primary amines.Acid hydrolysis, followed by acetylation, gives the (2S)-acetoxymethyl-4-isopropyltetrahydro-1,4-oxazine (21).A similar sequence has been applied to D-gulonolactone to give access to oxazines 33, 34, and 35. Keywords: Synthesis; D-Ribono-1,4-lactone; D-Gulono-1,4-lactone; Morpholine derivatives