140694-90-2

Upstream product

• 76-83-5 trityl chloride 
• 491-19-0 1,4-anhydro-D-ribitol 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 
• 5336-08-3 D-Ribono-1,4-lactone 
• 106707-71-5 2,3,5-tri-O-acetyl-1,4-anhydro-D-ribitol 
• 1122-58-3 dmap 
• 162635-55-4 1,4-anhydro-2,3-O-isopropylidene-5-O-(triphenylmethyl)-D-ribitol 
• 87-99-0 XYLITOL 
• 491-19-0 (2RS, 3RS, 4SR)-2-(hydroxymethyl)tetrahydrofuran-3,4-diol 

Downstream Products

• 3169-90-2 O²,O³-diacetyl-O⁵-trityl-DL-1,4-anhydro-xylitol 
• 162635-56-5 (2S)-2-O-(2-hydroxyethyl)-1-O-triphenylmethylglycerol 

Relevant academic research and scientific papers

IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY

The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) Wherein R1 includes an amino group. These compounds are particularly useful in the formulation and in vivo and ex vivo delivery of nucleic acid and protein therapeutics for preparing and implementing T cell transfection, gene editing, cancer therapies, cancer prophylactics, and in the preparation of vaccines.

Synthesis of novel carbohydrate based pyridinium ionic liquids and cytotoxicity of ionic liquids for mammalian cells

The large pool of naturally occurring carbohydrates with their diversity in chirality and structure led to the idea of a systematic investigation of carbohydrate based ILs. To this end, we investigated the influence of different ether groups, mainly methyl or ethyl ether, on the secondary OH groups as well as different configurations on physical properties such as melting point, thermostability and especially the influence on cell toxicity. For this investigation we chose α- and β-methyl-, β-allyl- and β-phenyl d-glucopyranose as well as four 1-deoxy-pentoses. In order to be able to classify the results, more ionic liquids with different structural motives were examined for cytotoxicity. Here, we present data that confirm the biocompatibility of such ILs consisting of naturally occurring molecules or their derivatives. The synthesized carbohydrate based ILs were tested for their suitability as additives in coatings for medical applications such as drug-eluting balloons.

A new route to some enantiomerically pure substituted morpholines from D-ribono- and D-gulono-1,4-lactones

D-Ribono-1,4-lactone, after acetalation, tritylation, and reduction, leads to a cyclization compound which gave with tosyl chloride 1,4-anhydro-2,3-O-isopropylidene-5-O-trityl-D-ribitol.The latter was transformed (acid hydrolysis, periodate oxidation, reduction, tritylation, and tosylation) into a ditosylated derivative 16, which was cyclized into morpholines by the action of primary amines.Acid hydrolysis, followed by acetylation, gives the (2S)-acetoxymethyl-4-isopropyltetrahydro-1,4-oxazine (21).A similar sequence has been applied to D-gulonolactone to give access to oxazines 33, 34, and 35. Keywords: Synthesis; D-Ribono-1,4-lactone; D-Gulono-1,4-lactone; Morpholine derivatives

Purinyl and pyrimidinyl tetrahydrofurans

Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts.