1407159-62-9Relevant academic research and scientific papers
Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an 'upside-down' binding pose
Vaidya, Aditya Sudheer,Neelarapu, Raghupathi,Madriaga, Antonett,Bai, He,Mendonca, Emma,Abdelkarim, Hazem,Van Breemen, Richard B.,Blond, Sylvie Y.,Petukhov, Pavel A.
, p. 6621 - 6627 (2013/01/14)
A novel series of HDAC8 inhibitors without a zinc-chelating hydroxamic acid moiety is reported. Photoaffinity labeling and molecular modeling studies suggest that these ligands are likely to bind in an 'upside-down' fashion in a secondary binding site pro
