1407163-75-0

Upstream product

• 1407163-70-5 (2S,5R)-hexane-1,2,5-triol 
• 264889-39-6 [(2S)-4-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxybutyl]-4-methylbenzenesulfonate 
• 666239-17-4 (2S)-4-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)butane-1,2-diol 
• 1407168-64-2 (2S,3E)-4-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-ene-1,2-diol 
• 3427-24-5 (2S,3E,5S)-1,2,5,6-tetrahydroxy-1,2:5,6-di-O-isopropylidene-hex-3-ene 
• 1407163-74-9 (2S,5R)-2-(benzyloxy)-5-(tert-butyldimethylsilyloxy)hexanal 
• 1407163-73-8 (2S,5R)-2-(benzyloxy)-5-(tert-butyldimethylsilyloxy)hexan-1-ol 

Downstream Products

• 1407163-68-1 ((2R,5S)-5-(benzyloxy)hept-6-yn-2-yloxy)(tert-butyl)dimethylsilane 
• 1407163-66-9 (5S,6S,10S,13R)-6,10-bis(benzyloxy)-2,2,3,3,5,13,15,15,16,16-decamethyl-4,14-dioxa-3,15-disilaheptadec-8-yn-7-one 
• 1407163-81-8 (2S,3S,6R,8R,11S)-3,11-bis(benzyloxy)-2,8-dimethyl-1,7-dioxaspiro[5.5]undecan-4-one 
• 1407163-82-9 (2S,3S,6S,8R,11S)-3,11-bis(benzyloxy)-2,8-dimethyl-1,7-dioxaspiro[5.5]undecan-4-one 

Relevant academic research and scientific papers

Stereoselective total synthesis of dinemasone A by double intramolecular hetero-Michael addition (DIHMA)

The first total synthesis of dinemasone A, a bioactive metabolite with a spiroketal moiety, is described. The main strategy for the construction of the spiroketal unit involves a double intramolecular hetero-Michael addition (DIHMA) of an ynone moiety. The thus obtained axial-equatorial mono anomeric spiroketal, on spiroepimerization with ZnBr2, was converted into the requisite axial-axial double anomeric spiroketal. The ynone moiety with four stereocentres, was prepared from a chiral propargylic alcohol (C5-C11 fragment) and a dihydroxy aldehyde (C1-C4 fragment), which in turn were obtained from d-mannitol and crotyl alcohol respectively.