14073-08-6Relevant academic research and scientific papers
A novel and efficient synthetic method of benzo[f]chromen-1-ones and phenyl-4h-chromen-4-one through photooxidative cyclization of 6-[(E)-2-arylvinyl]-4H-pyran-4-ones and 6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-4H-pyran-4-one
A?t-Baziz, Nabila,Hamdi, Safouane M.,Silva, Artur M.S.,Rachedi, Yahia,Hamdi, Maamar,Trari, Mohamed
, p. 1240 - 1245 (2015/04/27)
A rapid and efficient microwave-assisted transformation of 2-pyrones into 4-pyrones is reported. Then, a new photocatalytic oxidative cyclization of 6-[(E)-2-arylvinyl]-2-methyl-4H-pyran-4-ones and 2-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-4H-pyran-
Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I)
Xi, Mei-Yang,Sun, Zhong-Ying,Sun, Hao-Peng,Jia, Jian-Min,Jiang, Zheng-Yu,Tao, Lei,Ye, Ming,Yang, Xi,Wang, Ya-Jing,Xue, Xin,Huang, Jing-Jie,Gao, Yuan,Guo, Xiao-Ke,Zhang, Sheng-Lie,Yang, Ying-Rui,Guo, Qing-Long,Hu, Rong,You, Qi-Dong
supporting information, p. 364 - 371 (2013/10/01)
When exposed to electrophiles, human colorectal cancer cells (HCT116) counteract oxidative stress through activating NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway. To identify new activators, luciferase reporter gene assay was used to screen in-house database of our laboratory, leading to a novel α-pyrone compound 1 as a hit. 2 with 2-fluoro phenyl group exhibited the strongest ARE inductive activity in the first round structure-activity relationship (SAR) study. Biological studies showed the compound induced nuclear translocation of Nrf2 preceded by phosphorylation of ERK1/2. The data encouraged us to use 2 as lead and 20 derivatives were synthesized to discuss a more detailed SAR, leading to a more potent compound 9, which can be the starting compound for further modification.
Iodine (III) mediated synthesis of new 5-aryl-3-(4-hydroxy-6-methyl-2H- pyran-2-oxo-3-yl)-1-phenylpyrazoles from dehydrogenation of 5-aryl-3-(4-hydroxy- 6-methyl-2H-pyran-2-oxo-3-yl)-1-phenylpyrazolines
Prakash, Om,Kumar, Ajay,Kinger, Mayank,Singh, Shiv P.
, p. 456 - 460 (2007/10/03)
3-Cinnamoyl-4-hydroxy-6-methyl-2-pyrones (chalcone analogs of DHA) on condensation with phenylhydrazine in ethanol, yield 5-aryl-3-(4-hydroxy-6- methyl-2H-pyran-2-oxo-3-yl)-1-phenylpyrazolines which undergo smooth dehydrogenation to the corresponding pyra
A facile synthesis of 3,4-dihydro-2-pyronyl-1,5-benzodiazepine derivatives
Prakash, Om,Kumar, Ajay,Sadana, Anil,Singh, Shiv P.
, p. 2663 - 2667 (2007/10/03)
The reaction of o-phenylenediamine with 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrones (3a-i, chalcone analogs of dehydroactic acid) in ethanol-acetic acid provides a facile method for the synthesis of 3,4-dihydro-2-pyronyl-1,5-benzodiazepine derivatives (2a-i).
