1407597-82-3

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 3449-63-6 3-(4-fluorophenyl)pentan-1,5-dioic acid 
• 1407597-89-0 (R)-N-benzyl-3-(4-fluorophenyl)-5-hydroxypentanamide 
• 1407597-87-8 (S)-4-(benzylcarbamoyl)-3-(4-fluorophenyl)butanoic acid 
• 1407597-85-6 (3'S,4S)-5,5-di(2-methoxy-5-methylphenyl)-3-[3-(4-fluorophenyl)-4-benzylcarbamoyl-1-oxobutyl]-4-isopropyloxazolidin-2-one 

Relevant academic research and scientific papers

An enantiodivergent and formal synthesis of paroxetine enantiomers by asymmetric desymmetrization of 3-(4-fluorophenyl)glutaric anhydride with a chiral SuperQuat oxazolidin-2-one

The asymmetric desymmetrization of 3-(4-fluorophenyl)glutaric anhydride 9 with lithiated chiral oxazolidin-2-one 8 has been studied. The desymmetrized product was formed with >90% de and converted into known intermediates for both (+)- and (-)-paroxetines.