14079-43-7

Upstream product

• 115760-16-2 5-tert-butyl-1,3-bis(5-tert-butyl-2-methoxybenzyl)-2-methoxybenzene 
• 75-36-5 acetyl chloride 
• 14079-42-6 2,6-di(o-anisyl)anisole 
• 108-24-7 acetic anhydride 

Downstream Products

• 47827-60-1 2,6-Bis-(2-methoxy-5,β-dimethylaminoethylbenzyl)-4,β-dimethylaminoethylanisole 
• 14079-47-1 Tris-N,N-dimethylamide of 2,6-Bis(2-methoxy-5-carboxymethylbenzyl)-4-carboxymethylanisole 
• 14079-46-0 Tris-N-methylamide of 2,6-Bis(2-methoxy-5-carboxymethylbenzyl)-4-carboxymethylanisole 
• 14079-45-9 2,6-Bis(2-methoxy-5-carboxymethyl)-4-carboxymethylanisole 
• 14079-44-8 4,4'-({4,4'-dimethoxy-3,3'-[2-methoxy-5-(2-morpholin-4-yl-2-thioxo-ethyl)-m-phenylenedimethyl]-diphenyl}-bis-thioacetyl)-bis-morpholine 

Relevant academic research and scientific papers

Friedel-Crafts ipso-Acylations of 2-Substituted 4-tert-Butylanisoles and p-tert-Butylmethoxymetacyclophanes

Acylation of 1,n-bis(5-tert-butyl-2-methoxyphenyl)alkanes 6 with acid chloride or acid anhydride in the presence of Lewis acids afforded only the product arizing from two-fold ipso-acylation at the tert-butyl groups; similar reaction of 1,2-bis(5-tert-butyl-2-methoxy-3-methylphenyl)alkanes 8 led only to the recovery of the starting compounds, thus differing from the nitration of 8 with fuming HNO3 at room temperature which affords in quantitative yield the selective ipso-nitration product at the tert-butyl groups.However, the ipso-acylation reactions of 5,13-di-tert-butyl-8,16-dimethoxymeta-cyclophane 15 led to the first-reported direct introduction of an acyl group due to a through-space electronic interaction with the opposing benzene ring.In contrast the selective ipso-acylation reaction was not observed in the case of the larger ring sized macrocyclic meta-cyclophane, p-tert-butyltetramethoxycalix(4)arene.