14079-89-1Relevant academic research and scientific papers
Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of 2-Hydroxypyrimidine/Pyrimidin-2(1H)-one Tautomers
Feng, Guang-Shou,Chen, Mu-Wang,Shi, Lei,Zhou, Yong-Gui
, p. 5853 - 5857 (2018)
A facile access to optically active cyclic ureas was developed through palladium-catalyzed asymmetric hydrogenation of pyrimidines containing tautomeric hydroxy group with up to 99 % ee. Mechanistic studies indicated that reaction pathway proceed through
