1408062-95-2

Basic information

• Product Name: N'-[phenylmethylidene]piperazine-1-carbothiohydrazide
• Synonyms: N'-[phenylmethylidene]piperazine-1-carbothiohydrazide
• CAS NO: 1408062-95-2
• Molecular Weight: 248.352
• Mol File: 1408062-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-[phenylmethylidene]piperazine-1-carbothiohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-[phenylmethylidene]piperazine-1-carbothiohydrazide(1408062-95-2)
• EPA Substance Registry System: N'-[phenylmethylidene]piperazine-1-carbothiohydrazide(1408062-95-2)

Safety Data

• Hazardous Substances Data: 1408062-95-2(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 
• 7484-46-0 S-methyl benzenylmethylene hydrazine dithiocarboxylate 

Relevant articles and documents

Synthesis antimicrobial and anticancer activity of N′- arylmethylidene-piperazine-1-carbothiohydrazide

Ten newly synthesized thiosemicarbazones of piperazine (3a-3j) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae, protease, Candida albicans and Aspergillus niger. All the 10 compounds (3a-3j) were found to be better than Ciprofloxacin against B. subtilis and four molecules (3c, 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p-hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.