7484-46-0

Basic information

• Product Name: methyl 2-benzylidenehydrazinecarbodithioate
• CAS NO: 7484-46-0
• Molecular Formula: C₉H₁₀N₂S₂
• Molecular Weight: 210.3191
• Mol File: 7484-46-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 325°C at 760 mmHg
• Flash Point: 150.4°C
• Density: 1.16g/cm³
• Vapor Pressure: 0.000237mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: methyl 2-benzylidenehydrazinecarbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-benzylidenehydrazinecarbodithioate(7484-46-0)
• EPA Substance Registry System: methyl 2-benzylidenehydrazinecarbodithioate(7484-46-0)

Safety Data

• Hazardous Substances Data: 7484-46-0(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 100-52-7 benzaldehyde 
• 74-88-4 methyl iodide 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 

Downstream Products

• 76077-65-1 bis(S-methyl benzylidenehydrazinecarbodithioato)copper(II) 
• 41127-86-0 (C₉H₉N₂S₂)2Ni 
• 67-63-0 isopropyl alcohol 
• 74-93-1 methylthiol 
• 1408062-95-2 N'-[phenylmethylidene]piperazine-1-carbothiohydrazide 
• 1412901-05-3 [5-(benzylidenehydrazono)-4-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl](5-bromo-benzofuran-2-yl)methanone 
• 1279049-30-7 C₁₅H₁₃N₃O₂S 
• 1279049-54-5 C₁₅H₁₄N₄O₂S 
• 1252002-42-8 C₂₅H₁₉N₅O₃S 
• 1131274-94-6 C₂₄H₁₆N₄O₂S 
• 1117816-18-8 2-(1,2-diaza-3-phenylprop-2-enylidene)-3-phenyl-(1,3,4-thiadiazolin-5-yl)-5-chlorobenzo[d]furan-2-ylketone 
• 183675-32-3 Na⁽¹⁺⁾*Cu(C₆H₈N₂O₅)(C₉H₉N₂S₂)^(1-)*H₂O = Na[Cu(C₆H₈N₂O₅)(C₉H₉N₂S₂)]*H₂O 

Relevant articles and documents

Synthesis antimicrobial and anticancer activity of N′- arylmethylidene-piperazine-1-carbothiohydrazide

Ten newly synthesized thiosemicarbazones of piperazine (3a-3j) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae, protease, Candida albicans and Aspergillus niger. All the 10 compounds (3a-3j) were found to be better than Ciprofloxacin against B. subtilis and four molecules (3c, 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p-hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.

Synthesis and anticancer activity of thiosemicarbazones

Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC 50 of compound III-16 against SGC-7901 reaches to 0.032 μM.

A Homologation of Aldehydes and Ketones via the Formation and the Subsequent Pummerer-type Ring Fission of 2-Methylsulfinyl-5,6-dihydro-4H-1,3,4-thiadiazine Derivatives

A two-carbon homologation of aldehydes and ketones was achieved by using a sequence involving the formation and the subsequent Pummerer-type ring fission of 5,6-dihydro-4H-1,3,4-thiadiazine rings possessing methylsulfinyl functionality at C-2.