1408082-89-2Relevant academic research and scientific papers
Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2′-deoxyguanosine and their recognition by MGMT and Atl1
Abdu, Kabir,Aiertza, Miren K.,Wilkinson, Oliver J.,Grasby, Jane A.,Senthong, Pattama,Povey, Andrew C.,Margison, Geoffrey P.,Williams, David M.
, p. 11214 - 11216 (2012)
We show that DNA containing a conformationally-locked anti analogue of O6-alkylguanine is a poor substrate for human O6- methylguanine-DNA methyltransferase (MGMT) and the alkyltransferase-like protein, Atl1. This highlights the requ
