656830-85-2

Upstream product

• 656830-84-1 (1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime 
• 100643-27-4 2,6-diamino-3H-pyrimidin-4-one 
• 111-29-5 1 ,5-pentanediol 
• 4541-15-5 5-(benzyloxy)-1-pentanol 
• 78999-24-3 5-benzyloxy-1-pentanal 
• 100-44-7 benzyl chloride 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 5470-84-8 4-benzyloxybutanal 
• 252372-23-9 5-(benzyloxy)-1-nitropentan-2-ol 
• 656830-80-7 ({[(4E)-5-nitropent-4-enyl]oxy}methyl)benzene 
• 656830-82-9 2,6-diamino-5-[4-(benzyloxy)-1-(nitromethyl)butyl]pyrimidin-4(3H)-one 

Downstream Products

• 891769-96-3 2-amino-5-[2-(benzyloxy)propyl]-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-thione 
• 1408083-09-9 C₃₆H₃₆N₄O₇ 
• 1408083-12-4 C₄₅H₅₃N₆O₈P 
• 1408082-89-2 2-amino-5-(3-chloropropyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 
• 1408082-91-6 2-amino-5-(3-benzyloxypropyl)-4-chloro-7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythropentofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1408082-95-0 C₃₀H₃₀Cl₂N₄O₅ 

Relevant academic research and scientific papers

The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine

The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine are described. The crystal structures and pKa values of these and related O6-methylguanine analogues are reported. All compounds display higher pKa values than O 6-methylguanine with the sulfur-containing analogues being the more basic and exhibiting higher stability in aqueous solution. In a standard substrate assay with the human repair protein O6-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity. The Royal Society of Chemistry 2006.

The syntheses of tricyclic analogues of O6-methylguanine

The syntheses of the novel pyrrolo[2,3-d]pyrimidine-based heterocycles as tricyclic analogues of O6-methylguanine are described. Compound 5 is a weak inhibitor of human O6-alkylguanine DNA alkyltransferase.