140844-85-5Relevant academic research and scientific papers
Enantioselective ketone hydroacylation using noyori's transfer hydrogenation catalyst
Murphy, Stephen K.,Dong, Vy M.
supporting information, p. 5553 - 5556 (2013/05/22)
An enantioselective ketone hydroacylation enables the direct preparation of lactones from keto alcohols. The alcohol is oxidized in situ to an aldehyde, obviating the need to prepare sensitive keto aldehyde substrates. Noyori's asymmetric transfer hydroge
Catalytic enantioselective homoaldol reactions using binol titanium(IV) fluoride catalysts
Burke, E. Diane,Lim, Ngiap Kie,Gleason, James L.
, p. 390 - 392 (2007/10/03)
Titanium (IV) fluoride catalysts, prepared by the combination of (R)-2,2′-binaphthol and TiF4, are effective for promoting the homoaldol addition of 1-ethoxy-1-(trimethylsilyloxy)cyclopropane to aldehydes. The reactions proceed with ee's of up to 72% and are effective with a range of aldehyde substrates. The reactions show greatly improved enantioselectivity when compared to those catalyzed by titanium(IV) triflates. The increase in selectivity is presumed to result from the elimination of deleterious silicon cocatalysis.
Synthesis of the (4R,5R)-Isomer of 5-Hydroxy-6-phenyl-4-hexanolide, a Lateral Root-inducing Substance Isolated from Erwinia quercina
Sugai, Takeshi,Noguchi, Hajime,Ohta, Hiromichi
, p. 122 - 126 (2007/10/02)
Lipase-catalyzed enantioselective lactonization of racemic methyl 6-phenyl-4-hydroxy-5-hexynoate worked well to afford (R)-6-phenyl-5-hexyn-4-olide (42 percent yield, 81 percent e.e.).The e.e. of the product was enhanced to 97 percent by the repetition of
