1408443-17-3Relevant academic research and scientific papers
Facile synthesis of 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′- ones via iodine-promoted cascade cyclization
Zhu, Hai-Tao,Dong, Xue,Wang, Li-Jing,Zhong, Mei-Jin,Liu, Xue-Yuan,Liang, Yong-Min
, p. 10748 - 10750,3 (2012)
A novel and efficient synthetic approach to substituted 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones has been developed via an iodine-promoted cascade cyclization of 2-(3-hydroxy-3,3-diarylprop-1-yn- 1-yl)benzoates. This sequential cascade process is concisely conducted at room temperature. Subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodides proceed smoothly in good yields.
