140870-34-4

Basic information

• Product Name: 2-Propenoic acid, 2-fluoro-3-[5-(phenylmethoxy)-1H-pyrrolo[2,3-c]pyridin-3-yl]-, ethyl ester
• CAS NO: 140870-34-4
• Molecular Formula: C19H17FN2O3
• Molecular Weight: 340.354
• Mol File: 140870-34-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-fluoro-3-[5-(phenylmethoxy)-1H-pyrrolo[2,3-c]pyridin-3-yl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-fluoro-3-[5-(phenylmethoxy)-1H-pyrrolo[2,3-c]pyridin-3-yl]-, ethyl ester(140870-34-4)
• EPA Substance Registry System: 2-Propenoic acid, 2-fluoro-3-[5-(phenylmethoxy)-1H-pyrrolo[2,3-c]pyridin-3-yl]-, ethyl ester(140870-34-4)

Safety Data

• Hazardous Substances Data: 140870-34-4(Hazardous Substances Data)

Upstream product

• 185622-81-5 5-Benzyloxy-3-formyl-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 56795-92-7 1H-Pyrrolo<2,3-c>pyridine-3-carbaldehyde 
• 185622-83-7 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoro-1-hydroxy-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 100701-49-3 3-ethoxy-2-fluoro-3-oxopropionic acid 

Downstream Products

• 185622-85-9 3-(5-Benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-fluoro-propionic acid methyl ester 
• 140870-36-6 3-(5-Benzyloxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-propionic acid ethyl ester 
• 140870-35-5 5-Benzyloxy-3-(2-ethoxycarbonyl-2-fluoroethyl)-1H-pyrrolo<2,3-c>pyridine 

Relevant articles and documents

Synthesis of analogues of porphobilinogen

Syntheses are described of several analogues of porphobilinogen intended as substrates and/or inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). 2-Methylporphobilinogen 12 has been synthesised from α-methylpyrrole 6, whereas a phosphonate analogue 20 of porphobilinogen, 8,9-didehydroporphobilinogen 26 and 9-fluoroporphobilinogen 38 have all been made from the 1H-pyrrolo[2,3-c]pyridine 14. The best route to 38 avoids fluoroacrylate 28 because of loss of fluorine during reduction of the double bond.