140896-71-5 Usage
Uses
Used in Pharmaceutical Industry:
Phosphonic acid, [4-(6-azido-9H-purin-9-yl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique structure allows for the creation of various molecules with potential therapeutic applications.
Used in Agricultural Industry:
In the agricultural industry, Phosphonic acid,
[4-(6-azido-9H-purin-9-yl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl
]-1-butenyl]-, bis(1-methylethyl) ester, (E)- serves as a synthetic intermediate for the production of agrochemicals and pesticides. Its potential to be modified and combined with other molecules makes it a valuable asset in developing new and effective products for crop protection and enhancement.
Used in Industrial Applications:
Phosphonic acid, [4-(6-azido-9H-purin-9-yl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)is utilized as a synthetic intermediate in the development of various industrial materials. Its versatility in chemical reactions enables the production of a wide range of materials with specific properties, such as coatings, adhesives, and polymers.
Used in Medicinal Chemistry and Drug Discovery:
Phosphonic acid,
[4-(6-azido-9H-purin-9-yl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl
]-1-butenyl]-, bis(1-methylethyl) ester, (E)plays a crucial role in medicinal chemistry and drug discovery as a synthetic intermediate. Its unique structure and functional groups make it an ideal candidate for the development of new drugs and therapeutic agents, potentially leading to breakthroughs in the treatment of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 140896-71-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,0,8,9 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 140896-71:
(8*1)+(7*4)+(6*0)+(5*8)+(4*9)+(3*6)+(2*7)+(1*1)=145
145 % 10 = 5
So 140896-71-5 is a valid CAS Registry Number.
140896-71-5Relevant academic research and scientific papers
Antiviral phosphono-alken derivatives of purines
-
, (2008/06/13)
The present invention provides antiviral compounds of Formula (I), and pharmaceutically acceptable salts thereof: STR1 wherein X is --CH2 O or --CH2 ; R1 is hydroxy or amino; R2 is hydrogen or amino; R3/su
Novel acyclonucleotides: Synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine
Harnden,Parkin,Parratt,Perkins
, p. 1343 - 1355 (2007/10/02)
A series of phosphonoalkenyl and (phosphonoalkenyl)oxy derivatives of purines and a pyrimidine were synthesized. These compounds are the first reported acyclonucleotides which incorporate the α,β-unsaturated phosphonic acid moiety as the phosphate mimic and include compounds in which the acyclic substituent is attached to N-9 of a purine or N-1 of a pyrimidine by either a nitrogen-carbon or a nitrogen-oxygen bond. The phosphonoalkenyl-substituted compounds 7a-c, 8a-c, 9, 10, and 12 were prepared either by Mitsunobu coupling of alcohols with purine or pyrimidine derivatives or by alternative alkylations of the heterocyclic bases. The (phosphonoalkenyl)oxy derivatives 7d-g, 8d-g, and 11 were synthesized by coupling of alcohols with 9- hydroxypurines or a 1-hydroxypyrimidine under Mitsunobu conditions. The novel acyclonucleotides were tested for activity against herpes simplex types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), visna virus, and human immunodeficiency virus type 1 (HIV-1). Guanine derivatives were moderately to extremely cytotoxic, but the adenines were less toxic to cells. At the concentrations tested, (Z)-isomers in the unbranched series had no activity against herpes viruses or HIV-1. (E)-9- [(4-Phosphonobut-3-enyl)oxy]adenine (7d) displayed selective activity against HIV-1, (E)-2,6-diamino-9-(4-phosphonobut-3-enyl)purine (9) showed selective antiretrovirus activity, and (E)-9-[2-(hydroxymethyl)-4-phosphonobut-3- enyl]adenine (7c) showed selective antiherpesvirus (VZV and CMV) activity.
