140902-80-3

Upstream product

• 66031-93-4 tert-butyldimethylsilyl vinyl ether 
• 140902-79-0 (2RS,4SR)-4-acetoxy-2-benzyloxyethyl-3,4-dihydro-2H-pyran 
• 140902-76-7 (E,5RS)-7-benzyloxy-1-chloro-5-hydroxyhepten-3-one 
• 140902-78-9 (2R,4S)-2-(2-Benzyloxy-ethyl)-3,4-dihydro-2H-pyran-4-ol 
• 140902-77-8 (2RS)-2-(benzyloxyethyl)-2,3-dihydro-4H-pyran-4-one 
• 19790-60-4 3-Benzyloxypropanal 
• 140902-82-5 (2RS,6RS)-6-benzyloxyethyl-5,6-dihydro-2-methoxycarbonyl-methyl-2H-pyran 
• 140902-81-4 (2RS,6SR)-6-benzyloxyethyl-5,6-dihydro-2-methoxycarbonyl-methyl-2H-pyran 

Downstream Products

• 140902-83-6 (E,5SR)-6-<(2RS,6SR)-6-<2-benzyloxyethyl>-5,6-dihydro-2H-pyran-2-yl>-5-hydroxy-2-methylhexa-2-enal 
• 141041-72-7 (E,5RS)-6-<(2RS,6SR)-6-<2-benzyloxyethyl>-5,6-dihydro-2H-pyran-2-yl>-5-hydroxy-2-methylhexa-2-enal 

Relevant academic research and scientific papers

The total synthesis of swinholide A. Part 2: A stereocontrolled synthesis of a C1-C15 segment

The C1-C15 segment 3 of swinholide A was prepared in 10 steps (14% yield) from the methyl ketone 13. Key steps include (i) the asymmetric aldol reaction, 13 → 35, followed by cyclisation to give the dihydropyrone 36, (ii) the Ferrier

Stereocontrolled Synthesis of a C1-C15 Segment for the Marine Macrolides Swinholide A and Scytophycin C: Use of a Vinylogous Mukaiyama Aldol Reaction

The C1-C15 segment (+/-)-8 of swinholide A/scytophycin C was prepared in eight steps from (E)-4-chlorobut-3-en-2-one (10) in 19percent overall yield with 87percent diastereoselectivity.The C7 stereocenter was controlled by the novel, vinylogous Mukaiyama