140934-46-9Relevant academic research and scientific papers
Structure-activity relationship of indoloquinoline analogs anti-MRSA
Zhao, Min,Kamada, Tomonori,Takeuchi, Aya,Nishioka, Hiromi,Kuroda, Teruo,Takeuchi, Yasuo
, p. 5551 - 5554 (2015/11/17)
Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.
Bis-alkylamine indolo[3,2- B ]quinolines as hemozoin ligands: Implications for antimalarial cytostatic and cytocidal activities
Paulo, Alexandra,Figueiras, Marta,MacHado, Marta,Charneira, Catarina,Lavrado, Jo?o,Santos, Sofia A.,Lopes, Dinora,Gut, Jiri,Rosenthal, Philip J.,Nogueira, Fátima,Moreira, Rui
, p. 3295 - 3313 (2014/05/20)
To get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-alkylamine (2a-k) and N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity against chloroquine (CQ)-resista
SYNTHESIS OF 7-SUBSTITUTED INDOLOQUINOLINE DERIVATIVES
Chang, Ming-rong,Takeuchi, Yasuo,Hashigaki, Kuniko,Yamato, Masatoshi
, p. 147 - 152 (2007/10/02)
Indoloquinoline derivatives (7b-j> having the substituent, such as a nitro, amino, methyl, halogen, methoxy, or hydroxy group were prepared by three methods.
Synthesis and antitumor activity of fused quinoline derivatives. II. Novel 4- and 7-hydroxyindolo-[3,2-b]quinolines
Yamato,Takeuchi,Chang,Hashigaki
, p. 528 - 530 (2007/10/02)
Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivati
