140934-79-8Relevant academic research and scientific papers
Synthesis and antimicrobial activity of pyridines bearing thiazoline and thiazolidinone moieties
Hassan, Hoda Y.,El-Koussi, Nawal A.,Farghaly, Zeinab S.
, p. 863 - 866 (1998)
Two series of new pyridines bearing thiazoline (3a - n) and thiazolidinone (5a - e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a - g) with an appropriately substituted phenacyl bromide or chloroacetic ac
Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules
Saikia, Ananya Anubhav,Rao, Ramdas Nishanth,Maiti, Barnali,Balamurali, Musuvathi Motilal,Chanda, Kaushik
, p. 630 - 640 (2020/12/15)
In this work, a one-pot, telescopic approach is described for the combinatorial library of thiazolidine-2-imines. The synthetic manipulation proceeds smoothly via the reaction of 2-aminopyridine/pyrazine/pyrimidine with substituted isothiocyanates followed by base catalyzed ring closure with 1,2-dibromoethane to obtain thiazolidine-2-imines with broad substrate scope and high functional group tolerance. The synthetic strategy merges well with the thiourea formation followed by base catalyzed ring closure reaction for the thiazolidine-2-imine synthesis in a more modular and straightforward approach. The synthetic procedure reported herein represents a cleaner route toward thiazolidine-2-imines as compared to traditional methodologies. Moreover, the biological significance of combinatorially synthesized thiazolidin-2-imines has been investigated for their use as possible inhibitors for acetyl cholinesterase through molecular docking studies.
