1409917-68-5

Basic information

• Product Name: N-(trityl)-4-(2-(3-cyanopropyl)diisopropylsilylethynyl)benzylamine
• Synonyms: N-(trityl)-4-(2-(3-cyanopropyl)diisopropylsilylethynyl)benzylamine
• CAS NO: 1409917-68-5
• Molecular Weight: 554.85
• Mol File: 1409917-68-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(trityl)-4-(2-(3-cyanopropyl)diisopropylsilylethynyl)benzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(trityl)-4-(2-(3-cyanopropyl)diisopropylsilylethynyl)benzylamine(1409917-68-5)
• EPA Substance Registry System: N-(trityl)-4-(2-(3-cyanopropyl)diisopropylsilylethynyl)benzylamine(1409917-68-5)

Safety Data

• Hazardous Substances Data: 1409917-68-5(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 59528-27-7 p-iodobenzylamine hydrochloride 
• 1057407-31-4 [(3-cyanopropyl)diisopropylsilyl]acetylene 
• 1409917-67-4 N-(triphenylmethyl)-4-iodobenzylamine 
• 113641-37-5 3-(cyanopropyl)diisopropylsilyl chloride 

Downstream Products

• 1409917-69-6 N-(trityl)-4-(2-(3-formylpropyl)diisopropylsilylethynyl)benzylamine 

Relevant articles and documents

Silyl-based alkyne-modifying linker for the preparation of C-terminal acetylene-derivatized protected peptides

A novel linker for the synthesis of C-terminal acetylene-functionalized protected peptides is described. This SAM1 linker is applied in the manual Fmoc-based solid-phase peptide synthesis of Leu-enkephalin and in microwave-assisted automated synthesis of Maculatin 2.1, an antibacterial peptide that contains 18 amino acid residues. For the cleavage, treatment with tetramethylammonium fluoride results in protected acetylene-derivatized peptides. Alternatively, a one-pot cleavage-click procedure affords the protected 1,2,3-triazole conjugate in high yields after purification.