1409917-69-6Relevant articles and documents
Silyl-based alkyne-modifying linker for the preparation of C-terminal acetylene-derivatized protected peptides
Strack, Martin,Langklotz, Sina,Bandow, Julia E.,Metzler-Nolte, Nils,Albada, H. Bauke
, p. 9954 - 9958 (2013/01/15)
A novel linker for the synthesis of C-terminal acetylene-functionalized protected peptides is described. This SAM1 linker is applied in the manual Fmoc-based solid-phase peptide synthesis of Leu-enkephalin and in microwave-assisted automated synthesis of Maculatin 2.1, an antibacterial peptide that contains 18 amino acid residues. For the cleavage, treatment with tetramethylammonium fluoride results in protected acetylene-derivatized peptides. Alternatively, a one-pot cleavage-click procedure affords the protected 1,2,3-triazole conjugate in high yields after purification.