1409976-29-9Relevant academic research and scientific papers
METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS
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Paragraph 00111, (2014/10/18)
The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.
Palladium catalyzed direct α-arylation of α,α- difluoroketones with aryl bromides
Guo, Chen,Wang, Ruo-Wen,Qing, Feng-Ling
, p. 135 - 142,8 (2020/08/20)
The palladium-catalyzed direct α-arylations of α,α- difluoroketones with diverse aryl bromides have been developed by using rac-BINAP as ligand and Cs2CO3 as a mild base in xylene. This method provides an efficient and straightforward access to a variety of α-aryl-α,α-difluoroketones with broad substrate scope.
