874279-85-3

Upstream product

• 1259998-90-7 2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-(naphthalen-2-yl)-butan-1-one 
• 70039-22-4 4-(4-methylphenyl)methylene-2,6-di-tert-butyl-2,5-cyclohexanedien-1-one 

Downstream Products

• 71365-99-6 2-fluoro-1-(naphthalen-2-yl)ethan-1-one 
• 1313757-90-2 C₁₉H₁₅F₂NO 
• 1313758-06-3 (R)-3,3-difluoro-2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)propanenitrile 
• 1409976-27-7 2,2-difluoro-2-(4-methoxyphenyl)-1-(naphthalen-2-yl)ethanone 
• 1409976-30-2 2,2-difluoro-1-(naphthalen-2-yl)-2-o-tolylethanone 
• 1409976-29-9 2,2-difluoro-1-(naphthalen-2-yl)-2-(4-(trifluoromethyl)phenyl)ethanone 
• 1409976-28-8 2,2-difluoro-2-(4-fluorophenyl)-1-(naphthalen-2-yl)ethanone 
• 1409976-23-3 2,2-difluoro-1-(naphthalen-2-yl)-2-phenylethan-1-one 
• 1409976-26-6 2-(biphenyl-4-yl)-2,2-difluoro-1-(naphthalen-2-yl)ethanone 
• 1409976-25-5 2-(4-tert-butylphenyl)-2,2-difluoro-1-(naphthalen-2-yl)ethanone 
• 1409976-24-4 2,2-difluoro-1-(naphthalen-2-yl)-2-p-tolylethanone 

Relevant academic research and scientific papers

Microwave-assisted copper catalysis of α-difluorinated gem-diol toward difluoroalkyl radical for hydrodifluoroalkylation of para-quinone methides

Reported herein is a unified strategy to generate difluoroalkyl radicals from readily prepared α-difluorinated gemdiols by single electron oxidation. Under microwave irradiation, a catalytic amount of oxidant Cu(OAc)2 succeeds in the formation of transient difluoroalkyl radicals in situ, for the first time. The reaction features a simple protocol, short reaction time, scalability, and high yield. The synthetic utility of this new methodology was also explored for the synthesis of difluoroalkylated spiro-cyclohexadienones, which is an important core structure in natural products and pharmaceuticals.