1410036-91-7Relevant academic research and scientific papers
Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: Ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside
Kumamoto, Hiroki,Kawahigashi, Sachiko,Wakabayashi, Hiromi,Nakano, Tomohiko,Miyaike, Tomoko,Kitagawa, Yasuyuki,Abe, Hiroshi,Ito, Mika,Haraguchi, Kazuhiro,Balzarini, Jan,Baba, Masanori,Tanaka, Hiromichi
supporting information, p. 10993 - 10995 (2013/01/15)
4-exo-trig Cyclization reaction of a 4-pentenyl carbon radical containing the gem-difluoromethylene moiety adjacent to a radical accepting α,β-unsaturated ester was found to proceed efficiently to furnish a novel gem-difluorocyclobutane derivative. The cyclized product could be transformed into a gem-difluoromethylene analogue of oxetanocin T.
