141019-76-3

Upstream product

• 78246-81-8 benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside 
• 1005-56-7 phenylcarbonochloridothioate 

Downstream Products

• 79297-67-9 benzyl 2-acetamido-4,6-O-benzylidene-2,3-dideoxy-α-D-ribo-hexopyranoside 
• 58006-39-6 benzyl 2-acetamido-2,3-dideoxy-α-D-ribo-hexopyranoside 
• 131473-45-5 benzyl 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-α-D-ribo-hexopyranoside 
• 131473-47-7 2-acetamido-4,6-di-O-acetyl-2,3-dideoxy-α-D-ribo-hexopyranosyl dibenzyl phosphate 
• 141115-66-4 Benzyl-2-acetamido-4,6-O-benzyliden-2,3-didesoxy-α-D-xylo-hexopyranosid 
• 58006-41-0 Benzyl-2-acetamido-2,3-didesoxy-α-D-xylo-hexopyranosid 

Relevant academic research and scientific papers

Combined chemical-enzymic synthesis of deoxygenated oligosaccharide analogs: transfer of deoxygenated D-GlcpNAc residues from their UDP-GlcpNAc derivatives using N-acetylglucosaminyltransferase I

The 3"-,4"-, and 6"-deoxy analogs of UDP-GlcpNAc have been synthesized chemically and found to act as donor-substrates for N-acetylglucosaminyltransferase-I (GnT-I) from human milk.Incubation of UDP-GlcpNAc and these deoxy analogs with GnT-I in the presence of α-D-Manp-(1->3)-6)>-β-D-Manp-O(CH2)8COOMe gave β-D-GlcpNAc-(1->2)-α-D-Manp-(1->3)-6)>-β-D-Manp-O(CH2)8COOMe(6), and the deoxy analogs 12-14 where HO-3, HO-4, and HO-6, respectively, of the β-D-GlcNAc residue were replaced by hydrogen.The tetrasaccharide glycosides 6 and 12-14 were characterized by 1H-n.m.r. spectroscopy and evaluated as acceptors for GnT-II, the next enzyme in the pathway of biosynthesis of Asn-linked oligosaccharides.Deoxygenation of the 3-position of the β-D-GlcNAc residue of 6 completely abolished its acceptor activity, whereas removal of HO-4 or HO-6 caused only modest decreases in activity.