141036-83-1

Basic information

• Product Name: 3-Pentanone, 4-chloro-4-[(4-methylphenyl)sulfonyl]-1-phenyl-
• Synonyms: 3-Pentanone,4-chloro-4-[(4-methylphenyl)sulfonyl]-1-phenyl;2-chloro-2-(p-tolylsulfonyl)-5-phenyl-3-pentanone
• CAS NO: 141036-83-1
• Molecular Formula: C18H19ClO3S
• Molecular Weight: 350.866
• Mol File: 141036-83-1.mol

Chemical Properties

• Boiling Point: 495.9±45.0 °C(Predicted)
• Density: 1.240±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-Pentanone, 4-chloro-4-[(4-methylphenyl)sulfonyl]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pentanone, 4-chloro-4-[(4-methylphenyl)sulfonyl]-1-phenyl-(141036-83-1)
• EPA Substance Registry System: 3-Pentanone, 4-chloro-4-[(4-methylphenyl)sulfonyl]-1-phenyl-(141036-83-1)

Safety Data

• Hazardous Substances Data: 141036-83-1(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 134970-66-4 4-Chloro-1-phenyl-4-(toluene-4-sulfinyl)-pentan-3-ol 

Downstream Products

• 2021-28-5 ethyl dihydrocinnamate 
• 114468-26-7 α-chloroethyl para-tolylsulphone 
• 141054-32-2 1-Phenyl-4-(toluene-4-sulfonyl)-pentan-3-one 
• 141603-23-8 N,N-diethyl-2-benzyl-3-(p-tolylsulfonyl)butanamide 
• 141603-21-6 N,2-dibenzyl-3-(p-tolylsulfonyl)butanamide 
• 141603-22-7 N-<2-benzyl-3-(p-tolylsulfonyl)butanoyl>piperidine 

Relevant articles and documents

Favorskii Rearrangement and Carbon-Carbon Bond-Cleavage of α-Chloro-α-sulfonyl Ketones: A Synthesis of Carboxylic Acids and Their Derivatives from Aldehydes and Ketones

A method for synthesizing carboxylic acids and their derivatives from aldehydes and ketones via α-chloro-α-sulfonyl ketones is described.Acyclic α-chloro-α-sulfonyl ketones were synthesized from aldehydes and 1-chloroalkyl p-tolyl sulfoxides with carbon-carbon coupling in good overall yields.Cyclic α-chloro-α-sulfonyl ketones were synthesized from cyclic ketones in three steps in high overall yields.The Favorskii rearrangement of both acyclic and cyclic α-chloro-α-sulfonyl ketones with sodium hydride in the presence of amine gave β-sulfonyl amides with skeletal rearrangement in good to excellent yield.Amides and α,β-unsaturated amides were synthesized from the β-sulfonyl amides.Treatment of the cyclic α-chloro-α-sulfonyl ketones with alkoxides and hydroxide gave carboxylic esters and acids with cleavage of the ring in good to excellent yields.

Favorskii rearrangement of α-chloro β-keto sulfones with amines: A new synthesis of amides and α,β-unsaturated amides from aldehydes and ketons

The Favorskii rearrangement of α-chloro β-keto sulfones, which are easily synthesized from aldehydes and ketones, with amines gives β-sulfonyl amides in good yield. These β-sulfonyl amides are converted to amides and α,β-unsaturated amides by reduction or elimination of the sulfonyl group.

Lithium-Chlorine Exchange Reaction of α-Chloro α-Sulfonyl Ketones

Lithium-chlorine exchange of α-chloro α-sulfonyl ketones, easily prepared from 1-chloroalkyl aryl sulfoxides and aldehydes in good yields, with n-butyllithium gave α-sulfonyl ketones in high yields.Some trials to trap the enolate intermediate were carried