114468-26-7

Upstream product

• 141036-83-1 2-chloro-2-(p-tolylsulfonyl)-5-phenyl-3-pentanone 
• 134970-66-4 4-Chloro-1-phenyl-4-(toluene-4-sulfinyl)-pentan-3-ol 
• 50635-71-7 1-chloroethyl p-tolyl sulfoxide 
• 14195-15-4 α-(p-methylbenzenesulfonyl)propiophenone 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 141-52-6 sodium ethanolate 

Downstream Products

• 114468-20-1 5-phenyl-3-<1-(p-tolylsulfonyl)ethyl>-1,2,4-triazine 
• 114468-24-5 C₁₈H₁₇ClN₃O₂S^(1-)*K⁽¹⁺⁾ 
• 1262337-18-7 6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-ylmethyl acetate 
• 1262337-16-5 6-chloro-3-chloromethyl-8-[1-(p-methylphenylsulfonyl)ethyl]-1,2,4-triazolo[4,3-b]pyridazine 
• 114468-25-6 6-phenyl-5-<1-(p-tolylsulfonyl)ethyl>-1,2,4-triazine 
• 117508-94-8 1-(5-carbotert-butoxy-2-nitrophenyl)ethyl p-tolyl sulphone 
• 115909-73-4 C₂₅H₂₅N₃O₄S₂ 

Relevant academic research and scientific papers

Chemoselective mono halogenation of β-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones

The synthesis of α-halo β-keto-sulfones using potassium halide and hydrogen peroxide as a chemoselective mono halogenation reagent and the synthesis of α,α-symmetrical and asymmetrical dihalo β-keto-sulfones and α-halo, α-alkyl and β-keto-sulfones is described. Base induced cleavage of α-halo β-keto-sulfones, α,α-dihalo β-keto-sulfones, and α-halo, α-alkyl β-keto-sulfones afforded the corresponding halomethyl sulfones, dihalomethyl sulfones and haloalkyl sulfones.

Favorskii Rearrangement and Carbon-Carbon Bond-Cleavage of α-Chloro-α-sulfonyl Ketones: A Synthesis of Carboxylic Acids and Their Derivatives from Aldehydes and Ketones

A method for synthesizing carboxylic acids and their derivatives from aldehydes and ketones via α-chloro-α-sulfonyl ketones is described.Acyclic α-chloro-α-sulfonyl ketones were synthesized from aldehydes and 1-chloroalkyl p-tolyl sulfoxides with carbon-carbon coupling in good overall yields.Cyclic α-chloro-α-sulfonyl ketones were synthesized from cyclic ketones in three steps in high overall yields.The Favorskii rearrangement of both acyclic and cyclic α-chloro-α-sulfonyl ketones with sodium hydride in the presence of amine gave β-sulfonyl amides with skeletal rearrangement in good to excellent yield.Amides and α,β-unsaturated amides were synthesized from the β-sulfonyl amides.Treatment of the cyclic α-chloro-α-sulfonyl ketones with alkoxides and hydroxide gave carboxylic esters and acids with cleavage of the ring in good to excellent yields.

Favorskii rearrangement of α-chloro β-keto sulfones with amines: A new synthesis of amides and α,β-unsaturated amides from aldehydes and ketons

The Favorskii rearrangement of α-chloro β-keto sulfones, which are easily synthesized from aldehydes and ketones, with amines gives β-sulfonyl amides in good yield. These β-sulfonyl amides are converted to amides and α,β-unsaturated amides by reduction or elimination of the sulfonyl group.