141039-00-1Relevant articles and documents
Synthesis, molecular and crystal structure of 3'-N-alkylamino-3'-deoxythymidines and some biochemical properties of their phosphorous esters
Jasko,Fedorov,Atrazhev,Mozzherin,Novicov,Bochkarev,Gurskaya,Krayevsky
, p. 23 - 37 (2007/10/02)
Two approaches for the synthesis of 3'-N-alkylated 3'-amino-3'-deoxythymidines were developed, including both the reaction of 3'-amino-3'-deoxythymidine with aldehydes followed by the sodium borohydride reduction and preparation of the triphenylphosphinimine derivative and subsequent reaction with alkyl iodide. 5'-Triphosphates of the synthesized compounds were shown to be terminating substrates for human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases as well as for DNA polymerase β from rat liver. At the same time these compounds did not demonstrate the properties of a terminating substrate in DNA synthesis catalyzed by human DNA polymerase α, ε, and I from E. coli.
