141041-80-7

Basic information

• Product Name: Carbamic acid, (1-cyanoethyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (1-cyanoethyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl 1-cyanoethylcarbamate;tert-butyl N-(1-cyanoethyl)carbaMate;(1-Cyanoethyl)carbamic acid tert-butyl ester
• CAS NO: 141041-80-7
• Molecular Formula: C₈H₁₄N₂O₂
• Molecular Weight: 170.20896
• Product Categories: N-BOC
• Mol File: 141041-80-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 277℃
• Flash Point: 121℃
• Appearance: /
• Density: 1.021
• CAS DataBase Reference: Carbamic acid, (1-cyanoethyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (1-cyanoethyl)-, 1,1-dimethylethyl ester (9CI)(141041-80-7)
• EPA Substance Registry System: Carbamic acid, (1-cyanoethyl)-, 1,1-dimethylethyl ester (9CI)(141041-80-7)

Safety Data

• Hazardous Substances Data: 141041-80-7(Hazardous Substances Data)

Upstream product

• 3744-87-4 N-t-butyloxycarbonyl-DL-alanine 
• 78981-25-6 tert-butyl (1-amino-1-oxopropan-2-yl)carbamate 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51806-98-5 2-aminopropanenitrile 

Downstream Products

• 657423-49-9 tert-butyl [2-amino-2-(hydroxyimino-1-methylethyl)]carbamate 
• 96929-01-0 N-(tert-Butyloxycarbonyl)-DL-thioalaninamid 

Relevant articles and documents

BICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

Decarboxylative alkynylation and cyanation of carboxylic acids using photoredox catalysis and hypervalent iodine reagents

Alkynes and nitriles are important functional groups that serve as versatile building blocks in organic synthesis and find applications in material and medicinal sciences. A convenient and straightforward access to both classes of compounds under mild conditions is, therefore, highly desirable. Herein, we disclose the decarb-oxylative alkynylation and cyanation of broadly available carboxylic acids using photoredox catalysis and hyper-valent iodine reagents. Choices of both catalysts and reagents were crucial. Computational and experimental studies revealed two different possible mechanisms that are dictated by the oxidation potential of the reagents: radical for alkynylation, ionic for cyanation.

NEW COMPOUNDS

The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.