141045-77-4

Basic information

• Product Name: Ethyl trans-2-(N-Benzylamino)cyclopentanecarboxylate
• Synonyms: Ethyl trans-2-(N-Benzylamino)cyclopentanecarboxylate
• CAS NO: 141045-77-4
• Molecular Weight: 247.337
• Mol File: 141045-77-4.mol

Chemical Properties

• CAS DataBase Reference: Ethyl trans-2-(N-Benzylamino)cyclopentanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl trans-2-(N-Benzylamino)cyclopentanecarboxylate(141045-77-4)
• EPA Substance Registry System: Ethyl trans-2-(N-Benzylamino)cyclopentanecarboxylate(141045-77-4)

Safety Data

• Hazardous Substances Data: 141045-77-4(Hazardous Substances Data)

Upstream product

• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 100-46-9 benzylamine 
• 38052-23-2 ethyl (1R,2R)-2-aminocyclopentane-1-carboxylate 
• 100-52-7 benzaldehyde 
• 71032-10-5 (E)-ethyl 6-bromohex-2-enoate 
• 113709-50-5 Lithium N-benzyl-N-(trimethylsilyl)amide 
• 10412-92-7 ethyl 2-(benzylamino)cyclopent-1-ene-1-carboxylate 

Relevant articles and documents

Expanding dynamic kinetic protocols: Transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.

Saturated Heterocyles, 248. Synthesis of 2,4-Dioxo and 4-Oxo-2-thioxo Derivatives of Octahydrocyclopentapyrimidines

Unsubstituted and 1-benzyl-substituted cis-cyclopentapyrimidine-2,4-diones and cis-2-thioxocyclopentapyrimidin-4-ones 9a,b and 10a,b were prepared from the corresponding cis-2-amino-1-cyclopentanecarboxylates 3 and 5 with potassium cyanate and thiocyanate.It was found that the cis-derivatives 7a-h readily underwent ring closure, resulting in 3-substituted cis-2,4-cyclopentapyrimidinediones and cis-2-thioxocyclopentapyrimidin-4-ones 11a-d and 12a-d, whereas the trans counterparts 8a-d failed to cyclize, but gave hydrolyzed amino acid derivatives 13a,b and 14.This difference in the reactivities of the cis and trans isomers is a further example of the difficulty of preparing cyclopentane trans-fused six-membered 1,3-heterocycles by ring closure.

Chemo- and diastereoselective reduction of β-enamino esters: A convenient synthesis of both cis- and trans-γ-amino alcohols and β-amino esters

Convenient procedures for the chemo- and diastereoselective reduction of b-enamino esters 1 are described. Both cis- and trans-γ-amino alcohols 2 or b-amino esters 3 can be prepared by reduction of b-enamino esters 1, readily available starting materials, with the use of inexpensive reagents Na/i-PrOH or NaHB(OAc)3/AcOH, respectively, and the appropriate reduction conditions. The mechanisms and diastereoselectivities for the reductions are discussed. The relative configurations and conformations of the diastereoisomeric γ-amino alcohols 2 and β-amino esters 3 obtained are established by 1H and 13C NMR study and unequivocally set by their cyclic derivatives tetrahydro-1,3-oxazines 4.

New Type of Cyclization of α,β,χ,ψ-Unsaturated Dioic Acid Esters through Tandem Conjugate Additions by Using Lithium N-Benzyl-N-(trimethylsilyl)amide as a Nitrogen Nucleophile

Treatment of dimethyl (2E,6E)-2,6-octadienedioate with lithium N-benzyl-N-(trimethylsilyl)amide (LSA) gave 5-exo-trig ring closure products, methyl 3-(N-benzylamino)-2-(methoxycarbonyl)cyclopentane-1-acetates, through tandem conjugate additions.The relate