141056-86-2

Upstream product

• 655-15-2 2-bromo-2'-fluoroacetophenone 
• 141582-83-4 6-benzoyl-4-amino-6,7,8,9-tetrahydropyrido[3,4-e]pyrimidin-2-one 
• 15827-80-2 4-amino-3-cyano-1,2,5,6-tetrahydropyridine 
• 93-97-0 benzoic acid anhydride 
• 61082-68-6 1-benzoyl-4-amino-3-cyano-1,2,5,6-tetrahydropyridine 

Downstream Products

• 141056-92-0 9-(2-fluorobenzyl)-2-(2-fluorophenyl)-7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimidin-5(6H)-one 
• 141057-13-8 9-phenylacetyl-2-(2-fluorophenyl)-7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimidin-5(6H)-one 
• 478956-76-2 9-Isonicotinoyl-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]pyrido[3,4-e] pyrimidin-5(6H)-one 
• 141057-15-0 9-Nicotinoyl-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]pyrido[3,4-e] pyrimidin-5(6H)-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimdin-5(6H)-ones as functionally selective ligands of the benzodiazepine receptor site on the GABAA receptor

Benzodiazepines are allosteric modulators of the GABAA receptor. The traditionally prescribed benzodiazepines are nonselective and suffer from numerous side effects. Upon the identification of receptor subtypes, we set out to discover selective agents with the anticipation that these agents would have superior therapeutic potential. Herein, we describe the synthesis and biological evaluation of substituted 7,8,9,10-tetrahydroimidazo[1,2-c]pyrido[3,4-e]pyrimidin-5(6H)-ones and disclose that these compounds exhibit functional selectivity at the benzodiazepine receptor of GABAA receptor subtypes. The α2/α3-selective partial agonist 42 exhibited potent in vivo activity.

CERTAIN ARYL FUSED IMIDAZAOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 and W, X, A, B, C, D, E, R 3, R 4 are variables. These compounds are highly selective agonists, antagonists or inve

CERTAIN ARYL FUSED IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 and W, X, A, B, C, D, E, R 3, R 4 are variables. These compounds are highly selective agonists, antagonists or inve

CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The invention encompasses compounds of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof where n is 0, 1, or 2 and x is STR2 and R 1, R 2, R 3, Y, Z, W, T are defined variables. These compounds are highly selective agonists or