141074-77-3Relevant academic research and scientific papers
MODEL REACTIONS OF PYRUVATEDECARBOXYLASE: MECHANISMS OF THE FORMATION OF AN ALDEHYDE FROM THE 2-(α-HYDROXYBENZYL)THIAZOLUM ION
Vovk, A. I.,Murav'eva, I. V.
, p. 2407 - 2412 (2007/10/02)
In methanol and methanol-dichloroethane mixtures the rate of the decomposition of 3-benzyl-2-(α-hydroxybenzyl)-4-methylthiazolium iodide exceeds the rate of the decomposition of the corresponding chloride.Values of the rate constants of decomposition into benzaldehyde and thiazolium salt rise with fall in the solvating power of the solvent.The relation of the decomposition rate constant to the concentration of the alkali interacting with the 2-(α=hydroxybenzyl)thiazolium ion is nonlinear.The probable intermediate formed in the decomposition of thw 2-(α-hydroxybenzyl)thiazolium ion into benzaldehyde and a thiazolium salt may be a tetrahedral compound formed as a result of nucleophilic attack by the hydroxyl ion in the 2 position of the thiazolium ring.
