141075-03-8Relevant academic research and scientific papers
Preparation and reactions of magnesiated uracil derivatives
Abarbri, Mohamed,Knochel, Paul
, p. 1577 - 1578 (1999)
The I/Mg-exchange of 5-iodouracil derivatives affords the corresponding polyfunctional Grignard reagents which were found to react with various electrophiles in good yields.
Preparation of new polyfunctional magnesiated heterocycles using a chlorine-, bromine-, or iodine-magnesium exchange
Abarbri, Mohamed,Thibonnet, Jerome,Berillon, Laurent,Dehmel, Florian,Rottlaender, Mario,Knochel, Paul
, p. 4618 - 4634 (2007/10/03)
The reaction of heteroaryl iodides with i-PrMgBr (ca. 1.0 equiv) in THF provides the corresponding magnesiated heterocycles. Functional groups such as an ester, cyano, or chloride functions are tolerated in these new Grignard reagents if the exchange can be performed below -20 °C. This is the case for all heterocycles bearing electron-withdrawing groups or chelating functions facilitating the iodine-magnesium exchange. In many cases, the exchange can be extended to heteroaryl bromides, and a case of a chlorine-magnesium exchange is described with tetrachlorothiophene. This new preparation of functionalized heteroarylmagnesium compounds provides after reaction with various electrophiles a new entry to a broad range of polyfunctional pyridines, imidazoles, furanes, thiophenes, pyrroles, antipyrines, and uracil derivatives. The application of the halogenmagnesium exchange in the solid phase allows the performance of solid-phase synthesis, with potential applications for combinatorial chemistry.
Palladium-catalysed coupling of organotinsulfides with heteroaromatic halides
Jixiang,Crisp
, p. 683 - 686 (2007/10/02)
The palladium-catalysed coupling of 2- or 3-bromopyridine, 5-bromo or 2- chloro pyrimidine and 5-iodo-1,3-dibenzyluracil with phenyl tributylin sulfide gave the corresponding heterocyclic phenyl sulfide in good yield.
